NanoTube Automated Repository System for HTS

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$190,277.00
Award Year:
2010
Program:
SBIR
Phase:
Phase I
Contract:
1R43EB009626-01A2
Award Id:
96089
Agency Tracking Number:
EB009626
Solicitation Year:
n/a
Solicitation Topic Code:
NIBIB
Solicitation Number:
n/a
Small Business Information
ISTECH, INC., 2121 PENNSYLVANIA AVE, YORK, PA, 17404
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
626854046
Principal Investigator:
MARLIN YOHN
() -
Business Contact:
MARLIN YOHN
() -
Research Institution:
n/a
Abstract
DESCRIPTION (provided by applicant): Innovative products that reduce the costs and increase the quality and productivity of drug discovery research are more important than ever. We will rigorously validate prototypes of compound management products that wi ll help overcome limitations in the field of research materials management. Our NanoTube Automated Retrieval System (NARS) is based on technologies that are significantly more cost effective and more flexible in meeting the needs of more scientists than ot her solutions and resolves a problem that persists in the field; namely, that manual processing of compound libraries for high throughput screening (HTS) leads to their deterioration. The RandD proposed under Phase I will validate innovative repository sol utions in a working HTS laboratory. The Specific Aims are: 1. Validate the suitability of our NanoTube 'Single-Shot Storage' (NS) compound storage plates. The NS technology is the foundation of innovative NARS product lines we envision. 2. Demonstrate pro of of concept for the reliability of NARS technologies and designs in a working HTS environment. The strengths of this proposal are: 1) The NARS can be much more flexibly configured than prevailing systems. 2) Rapidly emerging biorespository markets creat e new opportunity and need for our approach. 3) Cost of consumables is 5-fold less expensive than other approaches (See Attachment 1). 4) Cost of NARS system is 3-fold less than prevailing systems (See Attachment 1). 5) The RandD will be carried out in an active compound management and HTS laboratory guided by a strategic alliance of experts in both automation engineering and drug discovery. The solutions we develop from this research will lead to products that enhance the quality of data from drug discove ry research and allow for more reliable identification of new drugs in accordance with the NIH mission of improving health. Important application in the field of forensics and genetic screening are envisioned, pending proof of concept from the proposed res earch. PUBLIC HEALTH RELEVANCE: The proposed studies will establish proof of concept for innovative Automated Repository Systems and technologies that support drug discovery research. This research will lead to products that increase the quality of data in drug discovery and serve other health-related research fields in accordance with the NIH mission of improving health.

* information listed above is at the time of submission.

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