A FIBER OPTIC FLUORENCE DETECTOR FOR THE LITHIUM ION

Award Information
Agency:
National Science Foundation
Amount:
$249,647.00
Program:
SBIR
Contract:
N/A
Solitcitation Year:
N/A
Solicitation Number:
N/A
Branch:
N/A
Award Year:
1991
Phase:
Phase II
Agency Tracking Number:
11760
Solicitation Topic Code:
N/A
Small Business Information
Covalent Associates Inc.
52 Dragon Court, Woburn, MA, 01801
Hubzone Owned:
N
Woman Owned:
N
Socially and Economically Disadvantaged:
N
Duns:
N/A
Principal Investigator
 Dr Margaret E Langmuir
 Senior Scientist
 () -
Business Contact
Phone: () -
Research Institution
N/A
Abstract
WE PROPOSE TO DEVELOP A FIBER OPTIC PROBE FOR LITHIUM ION BASED ON NEW FLUORESCENT LITHIUM ION CARRIERS IMMOBILIZED ONFIBER OPTIC BUNDLES BY LANGMUIR-BLODGETT FILM TECHNIQUES. IN PHASE I THE NEW FLUORESCENT IONOPHORE WILL BE SYNTHESIZEDAND TESTED FOR LI/NA SPECIFICITY. OPTICAL PROPERTIES WILL ALSO BE INVESTIGATED TO DETERMINE SUITABILITY FOR USE IN A FIBER OPTIC PROBE. IN PHASE II WE WILL SYNTHESIZE SOME ADDITIONAL ANALOGS OF THE FLUOROPHORES PREPARED IN PHASE I. THOSE HAVING THE BESTSPECIFICITIES AND OPTICAL PROPERTIES FOR LITHIUM WILL BE USED TO PREPARE FIBER OPTIC PROBES. THE PROBES WILL BE USEDTO DEVELOP A METHOD FOR DETERMINATION OF LI(+) ION IN THE BLOOD SERUM OF PATIENTS BEING TREATED WITH LITHIUM FOR MANIC/DEPRESSIVE PSYCHOSIS.

* information listed above is at the time of submission.

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