Lipophilic Calcium Fluoroionophores

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: 1 R43 GM50609-1,
Agency Tracking Number: 25093
Amount: $74,999.00
Phase: Phase I
Program: SBIR
Awards Year: 1994
Solicitation Year: N/A
Solicitation Topic Code: N/A
Solicitation Number: N/A
Small Business Information
Covalent Associates, Inc.
10 State Street, Woburn, MA, 01801
DUNS: N/A
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 Margaret Langmuir
 (617) 938-1140
Business Contact
Phone: () -
Research Institution
N/A
Abstract
We will synthesize and test new lipophilic fluorescent ionophores for measuring calcium ionconcentrations in aqueous solutions. The ionophores are designed to be soluble in synthetic membranesand to respond selectively to Ca2+ in a contacting aqueous solution by undergoing a shift in absorptionand emission to longer wavelengths. Theses compounds will be of primary interest for incorporating intoa fiber optic chemical sensor (FOCS). A FOCS device will be of use for determining the concentrationof calcium ion in biological fluids in vitro and ultimately in vivo. A device based on this design wouldbe valuable in the intensive care unit or other hospital facility.

* information listed above is at the time of submission.

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