New Diode-Laser Excitable Probes for Hypoxia Detection

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: N/A
Agency Tracking Number: 22026
Amount: $50,000.00
Phase: Phase I
Program: SBIR
Awards Year: 1993
Solitcitation Year: N/A
Solitcitation Topic Code: N/A
Solitcitation Number: N/A
Small Business Information
Covalent Associates, Inc.
10 State Street, Woburn, MA, 01801
Duns: N/A
Hubzone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 Jun-Rui Yang
 (617) 938-1140
Business Contact
Phone: () -
Research Institution
N/A
Abstract
We will synthesize and study fluorescent probes for hypoxic cells. The optical properties of the new compounds will be evaluated. Their ability to discriminate between hypoxic and oxic cells will be tested in cell cultures. These new probes will selectively bind to biomolecules in hypoxic cells. They will absorb in the 660-670 nm region to match the emission of newly available diode lasers. The long wavelength absorption, high molar extinction coefficients, and high quantum yields of the probe/biomolecule conjugates will allow sensitive detection of hypoxic cells. This will greatly improve the effectiveness of radiotherapy in cancer treatment.

* information listed above is at the time of submission.

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