Fluorescent Indicators for Cytosolic Lithium Ion

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$50,000.00
Award Year:
1993
Program:
SBIR
Phase:
Phase I
Contract:
n/a
Award Id:
22443
Agency Tracking Number:
22443
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
10 State Street, Woburn, MA, 01801
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
Christopher Blackburn
(617) 938-1140
Business Contact:
() -
Research Institute:
n/a
Abstract
We propose to synthesize and test new fluorescent indicators for the lithium ion in aqueous solution. The indicators are designed to be water soluble and to respond selectively to Li+ by undergoing a shift in absorption and emission wavelengths. The proposed compounds will be of primary interest for determining the concentration of cytosolic Li+ and for monitoring any flux of Li+ in single cells acted on by neurotransmitters. The indicators will be of use to cell physiologists and neuroscientists studying the influence of Li+ on the phosphatidylinositol cycle implicated in the mechanism by which Li+ functions in the treatment of manic-depressive psychosis. The indicators may also be of use for measuring the concentration of Li+ in the serum of patients undergoing therapy.

* information listed above is at the time of submission.

Agency Micro-sites


SBA logo

Department of Agriculture logo

Department of Commerce logo

Department of Defense logo

Department of Education logo

Department of Energy logo

Department of Health and Human Services logo

Department of Homeland Security logo

Department of Transportation logo

Enviromental Protection Agency logo

National Aeronautics and Space Administration logo

National Science Foundation logo
US Flag An Official Website of the United States Government