Gsh Receptor Probes to Study Cns Development/Dysfunction

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$715,121.00
Award Year:
1995
Program:
SBIR
Phase:
Phase II
Contract:
n/a
Award Id:
22375
Agency Tracking Number:
22375
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
10 State Street, Woburn, MA, 01801
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
Margaret E. Langmuir
(617) 938-1140
Business Contact:
() -
Research Institution:
n/a
Abstract
Preliminary evidence now exists that glutathione (GSH) acts as a neurotransmitter in the mammalian central nervous systems. Binding constants for receptor sites have been measured using radiolabeled GSH on synaptic membranes and on cultured astrocyte cells. There is evidence for GSH receptor sites in various other CNS structures as well. We will synthesize fluorescent GSH probes for the study of these receptor sites and measure their binding constants in competition with radiolabeled GSH. Fluorescence labeled probes with suitable binding constants will be used to study the distribution of binding sites in the CNS and other peripheral tissues and to examine second messenger (IP3) activation in cultured astrocytes. Fluorescent labeling on different GSH functional groups will also help elucidate the nature of the GSH receptor site.

* information listed above is at the time of submission.

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