Discovery of drugs for use in the treatment and prevention of HIV infection using

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: 1R43AT006121-01
Agency Tracking Number: AT006121
Amount: $268,332.00
Phase: Phase I
Program: SBIR
Awards Year: 2010
Solicitation Year: 2010
Solicitation Topic Code: NCCAM
Solicitation Number: PHS2010-2
Small Business Information
SYMBION DISCOVERY, INC.
SYMBION DISCOVERY, INC., BioInnovations Gateway, South Salt Lake, UT, 84115
DUNS: 829971014
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 DUANE RUFFNER
 (801) 983-0338
 DRUFFNER@SALUSINC.COM
Business Contact
 DUANE RUFFNER
Phone: (801) 414-6795
Email: shohle@attglobal.net
Research Institution
N/A
Abstract
DESCRIPTION (provided by applicant): Natural products are still the majority of therapeutic agents. However, they suffer from a difficulty in the creation of derivatives, and they can also be hard to supply. Derivatives are extremely important in the optimization of properties, such as toxicity or solubility, that are critical to development of therapeutics. Recently, it has become increasingly popular to create libraries of derivatives using genetic engineering of natural product biosynthetic genes. Even in the best libraries, the numbers of derivatives are in the hundreds or low thousands. Recently, we discovered an evolutionary pathway that could potentially be harvested to generate up to billions of derivatives. The compounds can be rapidly evolved to improve desired properties while minimizing unwanted effects. We have developed a system in which new activities can be pharmacologically optimized in a matter of days to weeks, exploring a huge diversity of unnatural natural products. In this project, we will develop this system to produce anti-HIV compounds for rapid development. The evolutionary feature of this proposal will allow leads to be rapidly optimized to overcome common problems in drug development. Our goal is to discover and develop anti-HIV candidate pharmaceuticals using cyanobactin technology. In pursuit of this goal, the project aims are to: 1: Construct and characterize a cyanobactin library. 2: Prepare and purify 15,000 to 20,000 cyanobactins from the library for use in high throughput screening. 3: Screen 15,000 to 20,000 cyanobactins from the library for anti-HIV leads using cell-based assays and identify the ten most fit leads suitable for further development in Phase II. PUBLIC HEALTH RELEVANCE: We will use innovative new technology to develop optimized anti-HIV agents with a variety of mechanisms. These agents will be leads for clinical development.

* information listed above is at the time of submission.

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