Not Available

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$200,000.00
Award Year:
2010
Program:
SBIR
Phase:
Phase I
Contract:
N43CO201000136
Agency Tracking Number:
N43CO201000136
Solicitation Year:
n/a
Solicitation Topic Code:
NCI
Solicitation Number:
n/a
Small Business Information
ORANOXIS, INC.
10366 ROSELLE ST, SAN DIEGO, CA, 92121-
Hubzone Owned:
N
Socially and Economically Disadvantaged:
N
Woman Owned:
N
Duns:
843649398
Principal Investigator:
DANIEL WANG
Business Contact:
(858) 692-2943
Research Institution:
n/a
Abstract

Different patients react very differently to chemotherapeutic cancer drugs, and are variably susceptible to drug side effects. Many patients are therefore currently not receiving adequate levels of those drugs. A personalized monitoring of toxic drug metabolites would greatly aid physicians to accurately personalize drug dosage.    We propose to develop a rapid oral fluid test of a panel of small drug metabolites for personalized diagnostic monitoring during treatment. We will utilize our patented design for a "discontinuous chromatographic capillary flow solid phase assay", The test can be designed both for home self-monitoring by the patient (over-the-counter device) and for use by physicians in clinics (point-of-care). The key features include: (i), highly sensitive detection of small molecule drug metabolites; (ii), an integrated oral fluid collection design that minimizes sample variability in viscosity, pH and contents, and provides sufficient sample backupvolumes for subsequent confirmatory tests; (iii), a user-friendly, low cost and disposable device.

* information listed above is at the time of submission.

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