Not Available

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: N43CO201000084
Agency Tracking Number: N43CO201000084
Amount: $182,050.00
Phase: Phase I
Program: SBIR
Awards Year: 2010
Solicitation Year: 2010
Solicitation Topic Code: NCI
Solicitation Number: PHS2010-1
Small Business Information
NANOIVD, INC., 637 Lucas Avenue, Suite 550, Los Angeles, CA, 90017
DUNS: 828761135
HUBZone Owned: N
Woman Owned: Y
Socially and Economically Disadvantaged: N
Principal Investigator
 Sunnie Kim
 (310) 529-1188
 s.kim@nanoivd.com
Business Contact
Phone: (310) 529-1188
Email: s.kim@nanoivd.com
Research Institution
N/A
Abstract
Silicon nanowire (SiNW) electrical biosensing shows promise for point-of-care test (POCT) applications which can lead to more rapid cancer diagnosis and early intervention. Our goal is to increase the sensitivity of SiNW-based sensors through novel design and fabrication. We will utilize the superlattice nanowire pattern transfer (SNAP) method to produce highly aligned arrays of SiNWs, each 25 nm wide and 3 mm long. NW doping level will be optimized and sectioned into several individual sensor arrays, electrical contacts to the NW sensors established, and each array integrated into a microfluidic channel to demonstrate that a single-stranded complementary oligonucleotide on counter electrode is able to significantly change the conductance of a SiNWs in saline solution when hybridized to a primary DNA strand. Proof of principle will be demonstrated by the reproducible detection of target species, K-ras mutated DNA sequences spiked in saline. Sensitivity and specificity as well as reliability testing will be performed. For sensitivity testing, 25 samples with and 25 without spiked target DNA sequence will be tested and interpreted. For specificity, 25 non-target DNA sequence sample will be tested. For reliability testing, target DNA spiked samples will be retested twice and at 24-hour intervals and reliability coefficients calculated.

* Information listed above is at the time of submission. *

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