Not Available

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$199,266.00
Award Year:
2010
Program:
SBIR
Phase:
Phase I
Contract:
N43CO201000081
Award Id:
96228
Agency Tracking Number:
N43CO201000081
Solicitation Year:
n/a
Solicitation Topic Code:
NCI
Solicitation Number:
n/a
Small Business Information
104 TW ALEXANDER DR Bldg # 4, RESEARCH TRIANGLE PARK, NC, 27709-
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
801431862
Principal Investigator:
SETHHOEDL
(919) 314-5515
shoedl@civatechoncology.com
Business Contact:
sbabcock@civatechoncology.com
Research Institute:
n/a
Abstract

The use of LDR brachytherapy after sub-lobar lung resection is the focus of a phase III NCI sponsored trial. Early clinical results from independent studies suggest that brachytherapy enables a singificant reduction in local recurrence rates versus surgery alone. Civatech Oncology and Allegheny General Hospital propose to design and fabricate a bio-absorbable, 2-dimensional sheet brachytherapy source to replace the current ad hoc method of sewing brachytherapy seeds to mesh. The new device will have a more uniform radiation profile, will allow for cutting to appropriately size the implant sheet and will be essentially uni-directional in terms of x-ray emissions. The latter point is important both in terms of minimizing radiation exposure to physicians and staff, but more particularly greatly reduces the dose to collateral normal tissues since the radiation from the sheet will impact the target lung tissue only. This new 2-dimensional device draws from the same fabrication methodology used by Civatech oncology to produce a novel linear LDR source for prostate cancer, device that has achieved FDA clearance. Other applications for the 2-D device will be evaluated, such as for sparing normal bowel in retroperitoneal and pelvic targets in regions of close margins or limited residual disease.

* information listed above is at the time of submission.

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