HIGH RESOLUTION COLLIMATORS FOR NUCLEAR MEDICINE

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: 1R43CA091762-01A1
Agency Tracking Number: CA091762
Amount: $382,686.00
Phase: Phase I
Program: SBIR
Awards Year: 2002
Solicitation Year: N/A
Solicitation Topic Code: N/A
Solicitation Number: N/A
Small Business Information
CREATV MICROTECH, INC., 11609 LAKE POTOMAC DR, POTOMAC, MD, 20854
DUNS: N/A
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 CHAMEI TANG
 (301) 983-1650
 CMTANG@CREATVMICROTECH.COM
Business Contact
 CHA-MEI TANG
Phone: (301) 983-1650
Email: CMTANG@CREATVMICROTECH.COM
Research Institution
N/A
Abstract
Collimators determine the resolution and sensitivity of the gamma cameras used in planar scintigraphy and single photon emission computed tomography (SPECT) in nuclear medicine. We propose to develop deep x-ray lithography/electroplating method to fabricate collimators. This new method has the following features: (a) Septal walls can be thinner than 100 pm. (b) The technology is applicable to parallel hole as well as converging collimators with continuous focus. ¿ Pixels can vary in shape and size in the same plane. (d) The collimator can have non-uniform thickness. High-resolution collimators with optimized sensitivity would be achievable. In Phase 1, we propose to: (a) fabricate parallel hole, lead collimators with septal walls thinner than 100 pm for two small animal gamma-cameras; (b) characterize the collimator t experimentally, and compare the results with theoretical predictions; ¿ develop electroplate and polishing technology for gold; (d) develop optimized collimator designs for converging collimators that are no longer restricted by existing collimator fabrication parameter limitations, (e) design various converging beam collimators for a small animal SPECT and (f) perform ray-tracing simulations of these designs. Progress in genome research has stimulated great interest in the development of molecular medicine; this field makes extensive use of knockout-gene, animal models in mice and rats. Non-invasive imaging techniques using radiotracers will play a major role in this effort and collimators is the most crucial element in determining the sensitivity and resolution of images in nuclear medicine.

* Information listed above is at the time of submission. *

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