SENSITIVE, INTEGRATING MULTI-WAVEGUIDE BIOSENSOR

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$245,970.00
Award Year:
2002
Program:
SBIR
Phase:
Phase I
Contract:
1R43CA094430-01
Award Id:
59858
Agency Tracking Number:
CA094430
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
CREATV MICROTECH, INC., 11609 LAKE POTOMAC DR, POTOMAC, MD, 20854
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
CHAMEI TANG
(301) 983-1650
CMTANG@CREATVMICROTECH.COM
Business Contact:
(301) 983-1650
CMTINC@CREATVMICROTECH.COM
Research Institute:
n/a
Abstract
Biosensors have wide applicability, such as medical diagnostics, infectious diseases, environmental sensing and food contamination, by detecting proteins, enzymes, bacteria, toxins, drugs, pollutants, DNA, etc. The development of better biosensors will have far-reaching societal impact, improving both health care and quality of life. We propose to develop an integrating multi-waveguide biosensor, where the illumination of the luminescent species on the sensing surface is not based on evanescent waves. The biosensor is capable of: - Low limits of determination - High sensitivity - High selectivity - Simultaneous analysis of multiple analytes - Low interference between waveguides, and - Enhanced discrimination between background and emitted signal. Preliminary experiments have demonstrated some of these features. The proposed research will optimize, fabricate and test this new type of biosensor. The Phase I research will: develop a method to analyze fluorescence on waveguide surfaces and implement it in a ray tracing code, applying the method to optimize waveguide designs, fabricate the best waveguide designs, experimentally test the waveguides with analyte, and compare the experimental data to reference experimental data and simulation results.

* information listed above is at the time of submission.

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