Xenograft Heart Valves--Biomechanics/Collagen Structure

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$74,576.00
Award Year:
1994
Program:
SBIR
Phase:
Phase I
Contract:
1 R43 HL53088-1,
Award Id:
25173
Agency Tracking Number:
25173
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
2211 New Market Pkwy, Ste 142, Marietta, GA, 30067
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
Steven Goldstein
(404) 952-1660
Business Contact:
() -
Research Institution:
n/a
Abstract
Though allograft human aortic valves are preferred for transplantation by virtue of their lowthrombogenicity and immunogenicity, superior hemodynamic performance, and extended durability, onlyabout 2,000 per year are implanted due to limited donated heart supply. An acellular porcine heart valvecould form the substrate of a heart valve graft after the removal of native cells and soluble proteins toablate its immunogenicity under conditions that do not alter the structural proteins of the leaflets. Thisextracellular matrix substrate can be then be repopulated with autogenous (recipient) fibroblasts whichwould synthesize proteins critical for the long-term maintenance of leaflet function as well as maskresidual xenoantigens. These studies will concentrate on the effects of the depopulation process on thebiomechanical functions of porcine heart valve leaflets with corollary examinations of the collagencontent and collagen cross-linking in treated tissues. Various depopulation paradigms will be comparedwith the goal of minimizing changes in stress/strain relationships, stress/relaxation relationships, ultimatetensile strength, and bending stiffness as compared with fresh cellular valve leaflets. While most of theexaminations will utilize tissue from adult pigs, it is clear that the type and stability of collagencross-links may change with age. Since certain target populations for heterograft valves may requireimplantation of smaller diameter valves, additional studies will focus on heart valve leaflets from juvenilepigs weighing 12-25 kg in which the diameter of the aortic valve is approximately 13-16 mm as opposedto 22-29 mm in adult animals. Since biomechanical properties and hemodynamic performance areclosely related, these examinations should help optimize the performance of depopulated heart valvesas graft elements.

* information listed above is at the time of submission.

Agency Micro-sites


SBA logo

Department of Agriculture logo

Department of Commerce logo

Department of Defense logo

Department of Education logo

Department of Energy logo

Department of Health and Human Services logo

Department of Homeland Security logo

Department of Transportation logo

Enviromental Protection Agency logo

National Aeronautics and Space Administration logo

National Science Foundation logo
US Flag An Official Website of the United States Government