IMPROVED SYNTHESIS OF RADIORECEPTOR LIGANDS

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$49,000.00
Award Year:
1990
Program:
SBIR
Phase:
Phase I
Contract:
n/a
Agency Tracking Number:
13703
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
Custom Synthesis Inc
3122 W Clay St, Seay Bldg #207, Richmond, VA, 23230
Hubzone Owned:
N
Socially and Economically Disadvantaged:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
Alan R Day
(804) 355-5405
Business Contact:
() -
Research Institution:
n/a
Abstract
THIS RESEARCH WILL EXPAND UPON PRELIMINARY STUDIES THAT DEMONSTRATED THE FEASIBILITY OF A SOLID-PHASE, FLOW-THROUGH DEVICE TO CARRY OUT CATALYTIC HYDROGEN TRANSFER REACTIONS. THESE STUDIES USED PALLADIUM-COATED GLASS FIBER FILTERS AS WELL AS SILICA/POLYVINYLCHLORIDE MEMBRANE. PHASE I RESEARCH WILL EVALUATE OTHER SUPPORTS, FOR EXAMPLE, CONTROLLED PORE GLASS AND SILICA/POLYETHYLENE MEMBRANES, AS MATRICES FOR THIS PROCEDURE. IN ADDITION, A THIOL SCAVENGER SUPPORT WILL BE PREPARED AND TESTED AS A DEVICE TOREDUCE OR ELIMINATE CATALYST POISONING. STUDIES WILL ALSO BE CARRIED OUT TO DETERMINE IF NICKEL DEPOSITED ON THESE MATRICES WILL SUPPORT CATALYSIS IN THE SAME WAY AS THE PALLADIUM-COATED SUPPORTS. THE UTILITY OF ISOPROPANOL AS A HYDROGEN DONOR IN CATALYTIC HYDROGEN TRANSFER REACTIONS WILLALSO BE STUDIED. BASED ON THE ABOVE, A DEVICE AND PROTOCOL WILL BE DEVELOPED THAT CAN CATALYZE DEHALOHYDROGENATION REACTIONS WITH THE ULTIMATE GOAL BEING DEVELOPMENT OF A FACILE METHOD FOR THE PREPARATION OF ISOTOPICALLY LABELED LIGANDS FOR USE IN A VARIETY OF BIOMEDICAL/BIOCHEMICAL APPLICATIONS.

* information listed above is at the time of submission.

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