IMPROVED SYNTHESIS OF RADIORECEPTOR LIGANDS

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: N/A
Agency Tracking Number: 13703
Amount: $49,000.00
Phase: Phase I
Program: SBIR
Awards Year: 1990
Solicitation Year: N/A
Solicitation Topic Code: N/A
Solicitation Number: N/A
Small Business Information
Custom Synthesis Inc
3122 W Clay St, Seay Bldg #207, Richmond, VA, 23230
DUNS: N/A
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 Alan R Day
 (804) 355-5405
Business Contact
Phone: () -
Research Institution
N/A
Abstract
THIS RESEARCH WILL EXPAND UPON PRELIMINARY STUDIES THAT DEMONSTRATED THE FEASIBILITY OF A SOLID-PHASE, FLOW-THROUGH DEVICE TO CARRY OUT CATALYTIC HYDROGEN TRANSFER REACTIONS. THESE STUDIES USED PALLADIUM-COATED GLASS FIBER FILTERS AS WELL AS SILICA/POLYVINYLCHLORIDE MEMBRANE. PHASE I RESEARCH WILL EVALUATE OTHER SUPPORTS, FOR EXAMPLE, CONTROLLED PORE GLASS AND SILICA/POLYETHYLENE MEMBRANES, AS MATRICES FOR THIS PROCEDURE. IN ADDITION, A THIOL SCAVENGER SUPPORT WILL BE PREPARED AND TESTED AS A DEVICE TOREDUCE OR ELIMINATE CATALYST POISONING. STUDIES WILL ALSO BE CARRIED OUT TO DETERMINE IF NICKEL DEPOSITED ON THESE MATRICES WILL SUPPORT CATALYSIS IN THE SAME WAY AS THE PALLADIUM-COATED SUPPORTS. THE UTILITY OF ISOPROPANOL AS A HYDROGEN DONOR IN CATALYTIC HYDROGEN TRANSFER REACTIONS WILLALSO BE STUDIED. BASED ON THE ABOVE, A DEVICE AND PROTOCOL WILL BE DEVELOPED THAT CAN CATALYZE DEHALOHYDROGENATION REACTIONS WITH THE ULTIMATE GOAL BEING DEVELOPMENT OF A FACILE METHOD FOR THE PREPARATION OF ISOTOPICALLY LABELED LIGANDS FOR USE IN A VARIETY OF BIOMEDICAL/BIOCHEMICAL APPLICATIONS.

* information listed above is at the time of submission.

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