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Therapeutic Vaccine for Prostate Cancer

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: 1 R43 CA66420-01,
Agency Tracking Number: 29207
Amount: $99,986.00
Phase: Phase I
Program: SBIR
Solicitation Topic Code: N/A
Solicitation Number: N/A
Solicitation Year: N/A
Award Year: 1995
Award Start Date (Proposal Award Date): N/A
Award End Date (Contract End Date): N/A
Small Business Information
3525 John Hopkins Court
San Diego, CA 92121
United States
HUBZone Owned: No
Woman Owned: No
Socially and Economically Disadvantaged: No
Principal Investigator
 Esteban Celis
 () -
Business Contact
Phone: () -
Research Institution

Cancer of the prostate is a serious health problem both in the US and worldwide. In the US alone ap165,000 new cases of prostate cancer are diagnosed each year (Cancer Statistics 12993, CA Cancer types of treatments such as immunotherapy should be considered. The purpose of the present studypossibility of inducing cytotoxic T lymphocyte (CTL) responses to prostate-related antigens as a meaantigen-specific immunotherapies for prostate cancer. Potential CTL antigenic epitopes have been idesequences of PSA and PAP. The identification of these potential CTL epitopes was achieved by selectiPSA and PAP that contain anchor binding motifs for MHC class I molecules. Several of these peptidesaffinity to purified MHC molecules. The ultimate goal of the Phase I study is to identify the immunorestricted peptides from PSA and PAP that are capable of eliciting CTL that will kill cells expressiproteins. If funded, the Phase II studies will be targeted to develop this peptide(s) into a CTL-indfor treatment of advanced prostate cancer.

* Information listed above is at the time of submission. *

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