Hip Joint Resurfacing with Functional Human Cartilage

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$236,632.00
Award Year:
2007
Program:
STTR
Phase:
Phase I
Contract:
1R41AR055414-01
Award Id:
85361
Agency Tracking Number:
AR055414
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
CYTEX THERAPEUTICS INC., BOX 2685, DURHAM, NC, 27715
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
783502466
Principal Investigator:
LISAFREED
(617) 253-0460
LFREED@MIT.EDU
Business Contact:
GEOFFREYERICKSON
() -
cytex.therapeutics@gmail.com
Research Institute:
MASSACHUSETTS INSTITUTE OF TEC

MASSACHUSETTS INSTITUTE OF TECHNOLOGY
77 MASSACHUSETTS AVE
CAMBRIDGE, MA, 2139

Nonprofit college or university
Abstract
DESCRIPTION (provided by applicant): Degenerative joint disease accounts for substantial human suffering at tremendous social and economic cost. While prosthetic joint replacement is a well-established procedure, a finite life span makes this treatment una cceptable for younger or active individuals who often require progressively complicated revision surgeries. The goal of this Phase I STTR is to develop an implant suitable for complete resurfacing of an osteoarthritic femoral head of the human hip joint an d proven ability to integrate with bone by using stem cells and a cartilage-mimetic scaffold. The two novelties of this work are: (i) accelerated generation of mechanically functional cartilage within a brief period of in vitro culture and (ii) resurfacing of an entire joint instead of a focal defect. We will create a hemispherical layer of cartilage that replicates the load-bearing properties of the native tissue by combining adult human stem cells with a biomaterial scaffold made by a new three-dimensiona l (3D) weaving technology and a novel, highly scalable cell culture device. Maturation and growth of the engineered tissue will be monitored by non-destructive MRI and biomechanical testing, and functional integration with vital bone will be assessed using a subcutaneous pouch model in an immunodeficient rodent. The combination of these emergent regenerative medical technologies is expected to provide a novel means of developing functional tissue engineered constructs that can improve the success of cartila ge repair procedures. This project represents a Phase I STTR to combine adult human stem cell and three-dimensional weaving technologies to create a layer of cartilage that can integrate with bone. The two primary novelties of this work are: (i) accele rated generation of mechanically functional cartilage within a brief period of in vitro culture and (ii) resurfacing of an entire joint instead of a focal defect. The ultimate goal of this study is to develop a tissue engineering approach that can be used to resurface large segments of the joint that have been affected by degenerative diseases such as osteoarthritis.

* information listed above is at the time of submission.

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