DEVELOPMENT

Award Information
Agency:
Department of Defense
Branch
Army
Amount:
$47,200.00
Award Year:
1986
Program:
SBIR
Phase:
Phase I
Contract:
n/a
Agency Tracking Number:
3815
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
Cyto Fluidics Inc
Eng Rsch Ctr - Bldg 334 Univ O, College Park, MD, 20742
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
JAMES F BROWN
(301) 454-5302
Business Contact:
() -
Research Institution:
n/a
Abstract
THIS PROPOSAL INVOLVES THE DESIGN, DEVELOPMENT, AND EVALUATION OF A MULTI-CHAMBER, LABORATORY-SCALE, SEMI-CONTINUOUS CELL CULTURE SYSTEM FOR MORE EFFICIENT, COST EFFECTIVE PRODUCTION OF MONOCLONAL ANTIBODIES (MAB). CONCEPTS WOULD BE INVESTIGATED WHICH WOULD ALLOW MODULAR CELL CHAMBERS TO BE FABRICATED FOR THE SIMULTANEOUS, ISOLATED GROWTH OF MULTIPLE ANIMAL CELL CULTURES UNDER INDEPENDENTLY CONTROLLED CONDITIONS. A CELL GROWTH MODULE AND PROPRIETARY MEMBRANE VALVE WOULD BE EVALUATEDF WITH ANIMAL CELLS IN PHASE I. IN PHASE II A FULLY-AUTOMATED 50 CHAMBER CELL CULTURE SYSTEM WOULD BE PROTOTYPE. THIS INSTRUMENT WOULD THEN BE MANUFACTURED AND MARKETED DURING PHASE III. OUR INSTRUMENT WOULD FACILITATE BIOLOGICAL RESEARCH EMPLOYING CELL CULTURE BY IMPROVING CELL VIABILITY, ENHANCING EXPERIMENTAL CONTROL AND FLEXIBILITY, AND REDUCING THE PROBABILITY OF CULTURE CONTAMINATION. THESE FEATURES AND THE CAPABILITY OF MAINTAINING MANY INDIVIDUALLY CONTROLLED CELL COLONIES WOULD ENHANCE THE PRODUCTION OF HYBRIDOMAS FOR MONOCLONAL PRODUCTION.

* information listed above is at the time of submission.

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