NUCLEAR MATRIX AND ACTIN - BIOMARKERS FOR BLADDER CANCER

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$49,999.00
Award Year:
1992
Program:
SBIR
Phase:
Phase I
Contract:
n/a
Award Id:
19108
Agency Tracking Number:
19108
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
2925 United Founders Boulevard, Oklahoma City, OK, 73112
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
Robert W Veltri
(405) 848-4100
Business Contact:
() -
Research Institute:
n/a
Abstract
CYTOSKELETAL AND NUCLEAR MATRIX PROTEINS (NMPS) PLAY AN IMPORTANT ROLE IN THE BIO-CHEMICAL EVENTS INVOLVED IN DIFFERENTIATION AND TRANSFORMATION OF MAMMALIAN CELLS. CERTAIN OF THESE MARKERS, F/G-ACTIN AND BLADDER CANCER-RELATED NMPS, PROVIDE A UNIQUE MEANS FOR EARLY IDENTIFICATION OF BLADDER CANCER AS WELL AS ASSESSMENT OF FIELD DISEASE EFFECTS. NEW METHODS OF ISOLATING, PURIFYING REAGENTS AND LABELING THESE BIOMARKERS, COMBINED WITH MAJOR ADVANCES IN AUTOMATED IMAGE CYTOPHOTOMETRY (BOTH OPTICAL DENSITY AND FLUORESCENCE-BASED) PROVIDE AN OPPORTUNITY TO DEVELOP MULTI-MARKER DIAGNOSTIC ASSAYS. CYTODIAGNOSTICS INC. (CDI), A NATIONAL ONCOLOGY REFERENCE LABORATORY, IS COLLABORATING WITH MATRITECH, INC. TO INVESTIGATE THE DUAL MARKER COMBINATION OF ACTIN/NMP TO IDENTIFY BLADDER CANCER CELLS IN CYTOLOGY SPECIMENS. MATRITECH IS AN EXPERT IN NUCLEAR MATRIX PROTEIN CHEMISTRY, WHILE CDI HAS EXPERTISE WITH ACTIN AND AUTOMATED IMAGE ANALYSIS. THE TWO COMPANIES WITH OKLAHOMA UNIVERSITY DEPARTMENT OF UROLOGY, WILL INVESTIGATE THE UTILITY OF ACTIN/NMP FOR DETECTION OF BLADDER CANCER, ASSESSMENT OF FIELD DISEASE DYNAMICS, RELATIONSHIP TO RECURRENCE, THERAPEUTIC RESPONSIVENESS, AND PROGRESSION. THE INSTRUMENTATION APPLIED TO THE PROJECT WILL INCLUDE FLOW CYTOMETRY AND QUANTITATIVE IMAGE CYTOPHOTOMETRY WITH ZEISS-IBAS AUTOMATED IMAGE SYSTEM HAVING UNIQUE SOFTWARE MODIFICATIONS.

* information listed above is at the time of submission.

Agency Micro-sites


SBA logo

Department of Agriculture logo

Department of Commerce logo

Department of Defense logo

Department of Education logo

Department of Energy logo

Department of Health and Human Services logo

Department of Homeland Security logo

Department of Transportation logo

Enviromental Protection Agency logo

National Aeronautics and Space Administration logo

National Science Foundation logo
US Flag An Official Website of the United States Government