Analytic Methods for Heterogeneous Multilevel Data

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$749,188.00
Award Year:
2007
Program:
SBIR
Phase:
Phase II
Contract:
4R44GM076846-02
Agency Tracking Number:
GM076846
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
DATA NUMERICA INSTITUTE, INC.
DATA NUMERICA INSTITUTE, INC., 6120 149TH AVE SE, BELLEVUE, WA, 98006
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
003849838
Principal Investigator:
EDWARD CHAO
(425) 591-7944
ECHAO@DATANUMERICA.COM
Business Contact:
() -
kwang@datanumerica.com
Research Institution:
n/a
Abstract
DESCRIPTION (provided by applicant): Multilevel data are very common in sociological, behavioral and biomedical researches. The data could come from longitudinal community surveys, genetic family studies or spatial-temporal studies to investigate some heal th outcomes. Typically, the interest focuses on the impact of some treatment intervention. Such data could be very complex when there are multiple levels of data structures. The data might have factors such as community, family, patient and repeated measur es over time nested or crossed in each other. For continuous response, hierarchical models such as linear mixed-effects models or latent variable models have been studied and applied. In the analysis, the major interest is to study the impact of specific c ause pathway on health outcome. Since the records in each cluster are often correlated, investigator has to adjust the heterogeneity within a cluster of observations or between clusters. Overdispersion is also very common in such data. The major interest o f this project is to investigate the analytic methods for continuous and discrete outcomes of the above nature. In this area, typically, people apply generalized linear mixed-effects models GLMM, marginal models or transition models to non-continuous data. The difficulties for such models such as GLMM is that estimation methods often have troubles to achieve unbiasness, consistency and efficiency. We are interested in the development of more robust methods to achieve these goals for continuous and discrete multilevel data with arbitrary dimension. The final result is a software library with flexible multilevel modeling approaches for the analysis of complex multilevel data. The software will be useful to biomedical researchers working on sociological, behavi oral and biomedical studies with complex data structures. Manuscripts and course packs will be developed to assist practitioners in applying appropriate methods and the software tool to their studies.

* information listed above is at the time of submission.

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