SBIR Phase I: High throughput microfluidic cell injection for cell reprogramming

Award Information
Agency: National Science Foundation
Branch: N/A
Contract: 0944910
Agency Tracking Number: 0944910
Amount: $150,000.00
Phase: Phase I
Program: SBIR
Awards Year: 2010
Solicitation Year: 2010
Solicitation Topic Code: BC
Solicitation Number: NSF 09-541
Small Business Information
Zaiput
955 Massachusetts Ave # 318, Cambridge, MA, 02139
DUNS: N/A
HUBZone Owned: Y
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 Andrea Adamo
 PhD
 (617) 230-4596
 andrea.adamo@gmail.com
Business Contact
 Andrea Adamo
Title: PhD
Phone: (617) 230-4596
Email: andrea.adamo@gmail.com
Research Institution
N/A
Abstract
This Small Business Innovation Research (SBIR) Phase I project supports research aimed at developing a new technology to deliver material into living cells. Delivery of material into living cells is a limiting step in a number of biological applications and innovative therapeutic approaches, including stem cells based therapy and regenerative medicine. In this project a novel technology to allow high throughput delivery of any type of molecule into any type of cell is explored. In this innovative system, living cells are lined up by flowing them in a microfluidic channel and the material to be delivered is shot on the cells with a miniaturized fluid jet that carries the molecules of interest. The broader impacts of this research are expected in the field of stem cell research and stem cell-based therapy. In particular, this microfluidic based system has the potential to boost the generation of induced pluripotent stem cells (iPS) , the rising star in the field of regenerative medicine, by eliminating the intracellular delivery problems that currently make generation of these cells extremely inefficient. Besides helping the biomedical community in realizing the commercial potential of iPS, the availability of the new intracellular delivery technology could benefit many different fields of biology, ranging from molecular biology to pharmaceutical research, and enable a number of new research applications.

* information listed above is at the time of submission.

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