PHENYLHYDRAZONES WITH ANTIESTROGEN ACTIVITIES

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: N/A
Agency Tracking Number: 11147
Amount: $440,486.00
Phase: Phase II
Program: SBIR
Awards Year: 1991
Solicitation Year: N/A
Solicitation Topic Code: N/A
Solicitation Number: N/A
Small Business Information
Dekk-tec Inc.
3839 Ulloa St #100, New Orleans, LA, 70199
DUNS: N/A
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 () -
Business Contact
Phone: () -
Research Institution
N/A
Abstract
SUBSTITUTED BENZOPHENONE PHENYLHYDRAZONES HAVE BEEN SYNTHESIZED AND HAVE DEMONSTRATED GOOD ANTIESTROGEN ACTIVITIES WITH LOW TO ABSENT INTRINSIC ESTROGENICITY (IN ANIMMATURE RAT UTERI ASSAY). 4,4(,)-DIHYDROXYBENZOPHENONE-2, 4-DINITROPHENYLHYDRAZONE (A-007) HAS DEMONSTRATED A 38-PERCENT CR WITH AN OVERALL 25- TO 50-PERCENT REDUCTION INTUMOR VOLUME OF DMBA-INDUCED RAT BREAST TUMORS. THIS IS IN CONTRAST TO A 125-PERCENT INCREASE IN TUMOR VOLUME PRODUCED BY TAMOXIFEN AND AN 850-PERCENT INCREASE SEEN IN THE CONTROLANIMALS. STUDIES USING THE COLONY-FORMING ASSAY (CFA) DOCUMENTED A-007'S ABILITY TO INHIBIT THE COLONIZATION OF HUMAN BREAST AND OVARIAN CANCERS AND NORMAL HUMAN ENDOMETRIAL CELLS. THESPECIFIC OBJECTIVES OF THIS PHASE I STUDY WILL BE TO INITIATE A-007 RAT AND MOUSE ACUTE/CHRONIC TOXICITY STUDIES AND TO DOCUMENT BONE MARROW TOXICITY OF A-007 USING THE GRANULOCYTE-MACROPHAGE COLONY-FORMING CELL ASSAY. DEKK-TEC, INC., WILL CONTINUE TO SYNTHESIZE AND SCREEN SUBSTITUTED HYDRAZONES FOR ANTIESTROGEN AND ANTICANCER PROPERTIES IN IMMATURE RATS AND IN ZR-75-1 HUMAN BREAST CANCER CELLS IN THE CFA.

* information listed above is at the time of submission.

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