PHENYLHYDRAZONES WITH ANTIESTROGEN ACTIVITIES

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$440,486.00
Award Year:
1991
Program:
SBIR
Phase:
Phase II
Contract:
n/a
Award Id:
11147
Agency Tracking Number:
11147
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
3839 Ulloa St #100, New Orleans, LA, 70199
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
() -
Business Contact:
() -
Research Institute:
n/a
Abstract
SUBSTITUTED BENZOPHENONE PHENYLHYDRAZONES HAVE BEEN SYNTHESIZED AND HAVE DEMONSTRATED GOOD ANTIESTROGEN ACTIVITIES WITH LOW TO ABSENT INTRINSIC ESTROGENICITY (IN ANIMMATURE RAT UTERI ASSAY). 4,4(,)-DIHYDROXYBENZOPHENONE-2, 4-DINITROPHENYLHYDRAZONE (A-007) HAS DEMONSTRATED A 38-PERCENT CR WITH AN OVERALL 25- TO 50-PERCENT REDUCTION INTUMOR VOLUME OF DMBA-INDUCED RAT BREAST TUMORS. THIS IS IN CONTRAST TO A 125-PERCENT INCREASE IN TUMOR VOLUME PRODUCED BY TAMOXIFEN AND AN 850-PERCENT INCREASE SEEN IN THE CONTROLANIMALS. STUDIES USING THE COLONY-FORMING ASSAY (CFA) DOCUMENTED A-007'S ABILITY TO INHIBIT THE COLONIZATION OF HUMAN BREAST AND OVARIAN CANCERS AND NORMAL HUMAN ENDOMETRIAL CELLS. THESPECIFIC OBJECTIVES OF THIS PHASE I STUDY WILL BE TO INITIATE A-007 RAT AND MOUSE ACUTE/CHRONIC TOXICITY STUDIES AND TO DOCUMENT BONE MARROW TOXICITY OF A-007 USING THE GRANULOCYTE-MACROPHAGE COLONY-FORMING CELL ASSAY. DEKK-TEC, INC., WILL CONTINUE TO SYNTHESIZE AND SCREEN SUBSTITUTED HYDRAZONES FOR ANTIESTROGEN AND ANTICANCER PROPERTIES IN IMMATURE RATS AND IN ZR-75-1 HUMAN BREAST CANCER CELLS IN THE CFA.

* information listed above is at the time of submission.

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