A-007: IMMUNE MODULATION OF HPV - CERVICAL CANCER

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$191,517.00
Award Year:
2001
Program:
SBIR
Phase:
Phase I
Contract:
n/a
Award Id:
53806
Agency Tracking Number:
1R43CA089772-01
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
4200 CANAL ST, STE A, NEW ORLEANS, LA, 70119
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
LEEMORGAN
() -
Business Contact:
(504) 488-5417
LRM1579@AOL.COM
Research Institute:
n/a
Abstract
DESCRIPTION: (Applicant's Description) 4,4'-Dihydroxybenzophenone-2,4-dinitrophenylhydrazone (A-007) has recently completed a Phase I clinical trial in advanced cancer with minimal toxicity and objective responses noted. Preliminary observations suggest that A-007 is able to stimulate lymphocyte mobilization when applied topically to normal skin, as well as, to metastatic cutaneous lesions. The specific objectives of this Phase I study will be to document A-007's ability to stimulate lymphocyte migration/activation in cancers associated with immunodeficiency related infections. A-007's functional groups will be modified to maximize pharmacophore activities. All new hydrazones, as well as, A-007 will be assayed in vitro/in vivo for lymphocyte stimulation properties. These studies will be expanded for use as a stimulant of local cervical immunity in a simian immunodeficiency virus (SIV) monkey model and as local treatment for young females with HPV-associated cervical cancers. PROPOSED COMMERCIAL APPLICATION: 4,4'-Dihydroxybenzophenone-2, 4-dinitrophenylhydrazone (A-007) is showing lymphocyte stimulation and anticancer activities in clinical trials. A new agent with anticancer/immune modulation activity in HPV associated cervical cancer would have wide use as a single agent or in combinations therapy.

* information listed above is at the time of submission.

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