PROTECTIVE TREATMENT FOR CATHETERS

Award Information
Agency:
Department of Health and Human Services
Branch:
N/A
Amount:
$50,000.00
Award Year:
1987
Program:
SBIR
Phase:
Phase I
Contract:
N/A
Agency Tracking Number:
7321
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
Denver Surgical Developments
6851 Highway 73, Evergreen, CO, 80439
Hubzone Owned:
N
Socially and Economically Disadvantaged:
N
Woman Owned:
N
Duns:
N/A
Principal Investigator
 JOHN B NEWKIRK D SC
 (303) 674-5294
Business Contact
Phone: () -
Research Institution
N/A
Abstract
THE LONG-TERM OBJECTIVE OF THIS RESEARCH IS TO MAKE COMMERCIALLY AVAILABLE CENTRAL VENOUS CATHETERS (CVC) THAT HAVE BEEN CHEMICALLY TREATED TO REDUCE THEIR TENDENCY TO INDUCE INFECTIONS, THEREBY BRINGING MAJOR HUMANITARIAN BENEFITS AND SUBSTANTIAL REDUCTIONS IN HOSPITAL CARE COSTS. SPECIFICALLY, DENVER SURGICAL DEVELOPMENTS, INC. WILL: (1) APPLY AN ALREADY DEVELOPED PROCESS FOR ANTIMICROBIAL PROTECTION OF SILICONE RUBBER TO A COMMONLY USED CVC (HICKMAN) DEVICE; (2) DETERMINE THE DURATION AND LEVELS OF ANTIMICROBIAL ACTIVITY OF OPTIMALLY TREATED CATHETERS DURING PERFUSION WITH SALINE, NUTRITIONAL, AND ONCOTHERAPEUTIC SOLUTIONS; (3) DETERMINE THE DEGREES OF PROTECTION OF TREATED CATHETERS AGAINST LUMEN COLONIZATION IN VITRO; (4) DETERMINE THE BIOCOMPATIBILITY IN MOUSE TISSUE OF THE TREATED CATHETER MATERIAL; AND (5) DETERMINE THE EFFECTS OF NORMAL STORAGE ON ANTIBACTERIAL ACTIVITY AND TENSILE STRENGTH OF TREATED CATHETERS.

* information listed above is at the time of submission.

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