EVALUATION OF A RETROVENOUS MYOCARDIAL PERFUSION SYSTEM

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$382,000.00
Award Year:
1986
Program:
SBIR
Phase:
Phase II
Contract:
n/a
Award Id:
1518
Agency Tracking Number:
1518
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
Deseret Research Company Inc. (Currently Deseret Research Company Inc)
520 Wakara Way, Salt Lake City, UT, 84108
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
Jeffrey L. Peters
() -
Business Contact:
() -
Research Institution:
n/a
Abstract
RETROVENOUS DIASTOLIC MYOCARDIAL PERFUSION (RVDP) WITH OXYGENATED BLOOD VIA THE CORONARY SINUS AND CORONARY VEINS HAS BEEN SHOWN EXPERIMENTALLY TO PROVIDE 45% OF THE NORMAL CORONARY BLOOD FLOW. RVDP THERAPY COULD SIGNIFICANTLY ALTER THE MORBIDITY OF PATIENTS WITH CORONARY ARTERY DISEASE AND ACUTE MYOCARDIAL ISCHEMIA. CURRENT EXPERIMENTAL RVDP CATHETERS REQUIRE A SECOND ARTERIAL SOURCE OF OXYGENATED BLOOD AND ABNORMALLY ELEVATE VENOUS PRESSURES. SINGLE, TRIPLE LUMEN RVDP CATHETERS WILL BE FABRICATED AND BENCH TESTED WITH ROLLER PUMP, PULSE CHAMBER, MEMBRANE OXYGENATOR AND CONTROL MODULE. SAFE BOUNDARY CONDITIONS OF RVDP PRESSURE AND FLOW WILL THEN BE EVALUATED BY ACUTE EXPERIMENTS IN THREE NORMAL SHEEP FOR FEASIBILITY AND TO DETERMINE IF MEAN CORONARY SINUS AND VENOUS PRESSURES CAN BE REDUCED WITH ACTIVE CORONARY VENOUS DECOMPRESSION. RVDP WILL THEN BE APPLIED IN THREE NORMAL SHEEP FOR 6 HOURS TO TEST FOR ANY MYOCARDIAL OR VEIN DAMAGE. RVDP WILL ALSO BE APPLIED IN THREE SHEEP 1/2 HOUR AFTER CORONARY ARTERY LIGATION TO DETERMINE PERCENT SALVAGE OF INJURED MYOCARDIUM "AT RISK". RVDP WILL HAVE A SIGNIFICANT THERAPEUTIC AND COMMERCIAL IMPACT ON THE TREATMENT OF MYOCARDIAL ISCHEMIA AND CARDIOGENIC AND CARDIOGENIC SHOCK, AS A DRUG DELIVERY SYSTEM (E.G. ST TOKINASE, CARDIOPLEGIA) AND AS A ROUTINE THERAPY FOR PATIENTS UNDERGOING PERCUTANEOUS TRANSLUMINAL ANGIOPLASTY, CARDIAC DIAGNOSTIC PROCEDURES OR INTRA-AORTIC BALLOON PUMPING.

* information listed above is at the time of submission.

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