THIS STUDY IS DESIGNED TO DEVELOP AND EVALUATE A METHOD OF REPLACING A HOLLOW VISCUS WITH A PROSTHESIS THAT ALLOWS PRIMARY MUCOSAL HEALING AND INCORPORATION OF THE PROSTHETIC INTO THE HEALING PROCESS.

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: N/A
Agency Tracking Number: 4876
Amount: $47,000.00
Phase: Phase I
Program: SBIR
Awards Year: 1986
Solicitation Year: N/A
Solicitation Topic Code: N/A
Solicitation Number: N/A
Small Business Information
Deseret Research Company Inc
520wakara Way, Salt Lake City, UT, 84108
DUNS: N/A
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 RICHARD E HOFFER
 PRINCIPAL INVESTIGATOR
 (801) 584-3232
Business Contact
Phone: () -
Research Institution
N/A
Abstract
THIS STUDY IS DESIGNED TO DEVELOP AND EVALUATE A METHOD OF REPLACING A HOLLOW VISCUS WITH A PROSTHESIS THAT ALLOWS PRIMARY MUCOSAL HEALING AND INCORPORATION OF THE PROSTHETIC INTO THE HEALING PROCESS. HEALING OF A FULL THICKNESS ISOLATED BOWEL SEGMENT TO 2 TYPES OF A HOLLOW VISCUS PROSTHESIS WILL BE EVALUATED IN DOGS. BOTH TYPES OF PROSTHESIS WILL CONSIST OF AN OUTER RIGID MESH AND A BIO- DEGRADABLE MIDDLE LAYER. THE TYPE A PROSTHESIS WILL HAVE ANINNER IMPERVIOUS LAYER, THE TYPE B PROSTHESIS WILL NOT. THEPROSTHESES WILL BE EVALUATED AT VARIOUS POSTIMPLANTATION TIMES OF UP TO AND INCLUDING 60 DAYS. EVALUATION OF HEALINGPATTERNS OF THE PROSTHESES AND MUCOSAL REGENERATION, INFECTION, CONNECTIVE TISSUE INGROWTH, REJECTION, AND STRICTURE WILL BE PERFORMED BY GROSS EXAM AND LIGHT MICROSCOPY.

* information listed above is at the time of submission.

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