Construction of Vascular Structures with Human Tropoelastin

Award Information
Agency: National Science Foundation
Branch: N/A
Contract: 0945065
Agency Tracking Number: 0945065
Amount: $199,213.00
Phase: Phase I
Program: SBIR
Awards Year: 2010
Solicitation Year: 2010
Solicitation Topic Code: BC
Solicitation Number: NSF 09-541
Small Business Information
PMB 13419, 2675 W HWY 89A, Sedona, AZ, 86336
DUNS: 828302104
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 Burt Ensley
 (928) 203-4127
Business Contact
 Burt Ensley
Title: PhD
Phone: (928) 203-4127
Research Institution
This Small Business Innovation Research (SBIR) Phase I project proposes to make new blood vessels by using a synthesized human protein as a guide for growing human cells into tissues. The guide will be molded into a tubular shape. The protein, a water soluble form of human elastin can be produced by fermentation and will be purified, mixed with a catalyst and cast into tubular shaped molds made of glass or plastic. After the protein has set up in the tubular mold, it will be removed, tested for its strength and ability to stretch, and mixed with human epithelial cells in tissue culture media. The cells will be allowed to grow on and within the solidified protein to form a combination of a strong, elastic vessel surrounded by layers of human cells. The broader impacts of this research are the availability of new and better performing blood vessel material for dialysis patients. Dialysis patients experience problems with damage to their blood vessels during the dialysis procedure. These complications currently cost a total of $1.5 billion extra. Reducing the costs, pain and complications by using a new vascular material represents a large benefit to patients and physicians.

* Information listed above is at the time of submission. *

Agency Micro-sites

SBA logo
Department of Agriculture logo
Department of Commerce logo
Department of Defense logo
Department of Education logo
Department of Energy logo
Department of Health and Human Services logo
Department of Homeland Security logo
Department of Transportation logo
Environmental Protection Agency logo
National Aeronautics and Space Administration logo
National Science Foundation logo
US Flag An Official Website of the United States Government