ECCENTRIC CONTRACTIONS EFFECTS ON MUSCULOSKELETAL AGING

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$37,000.00
Award Year:
1987
Program:
SBIR
Phase:
Phase I
Contract:
n/a
Award Id:
7076
Agency Tracking Number:
7076
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
4001-32 Northwest 43rd St, Gainesville, FL, 32607
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
KEITH M JOHNSTON
(904) 392-4251
Business Contact:
() -
Research Institute:
n/a
Abstract
OSTEOPOROSIS, DEGENERATIVE JOINT DISEASE, AND PRIMARY MUSCLE ATROPHY ARE THREE AGE-RELATED DISORDERS OF THE MUSCULOSKELETAL SYSTEM. OSTEOPOROSIS AFFECTS 90 PERCENT OF WOMEN OVER 75 YEARS, OSTEOARTHRITIS AFFLICTS 80 PERCENT, AND MUSCLE ATROPHY IS PROGRESSIVE WITH AGE. PHYSICAL CONDITIONING RETARDS BONE LOSS, STABILIZES DETERIORATED JOINTS, AND PREVENTS MUSCLE ATROPHY. THE MOST EFFICIENT STIMULUS TO PRODUCE THESE EFFECTS IS THERAPY UTILIZING SUBMAXIMAL ECCENTRIC MUSCLE CONTRACTION. EXERCISE OF THIS TYPE GENERATES AN EQUIVALENT TRAINING EFFECT WITH LESS ENERGY EXPENDITURE AND LESS CARDIOVASCULAR STRESS. THERE ARE PRESENTLY NO ISOTONIC ECCENTRIC DEVICES AVAILABLE TO STUDY EXERCISE IN WHICH THE RESISTANCE IN THE LIFTING PHASE OF THE CYCLE CAN BE DIFFERENT FROM THE RESISTANCE DURING THE LOWERING PHASE. PHASE I WILL INVOLVE DEVELOPMENT OF A MECHANISM WITH WHICH ECCENTRIC MUSCLE CONDITIONING CAN BE PERFORMED. THE APPLICATION OF THE PRINCIPLES LEARNED FROM THIS PROJECT MAY INCREASE FUNCTION AND ACTIVITY FOR POSTSURGICAL PATIENTS, NEUROLOGICALLY IMPAIRED INDIVIDUALS, AND THE ELDERLY.

* information listed above is at the time of submission.

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