VIRUSES

Award Information
Agency:
Department of Defense
Branch
Army
Amount:
$56,056.00
Award Year:
1986
Program:
SBIR
Phase:
Phase I
Contract:
n/a
Award Id:
3835
Agency Tracking Number:
3835
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
Po Box 4338 - 212 Durham Ave, Metuchen, NJ, 08840
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
DR RINALDO PAGNUCCO
(201) 549-4011
Business Contact:
() -
Research Institute:
n/a
Abstract
IT IS IMPORTANT TO BE ABLE TO SCREEN BLOOD SAMPLES FOR THE PRESENCE OF PATHOGENIC VIRUSES SUCH AS HTLV-III, THE CAUSITIVE AGENT IN ACQUIRED IMMUNE DEFICIENCY SYNDROME (AIDS). THIS PROPOSAL DETAILS A NOVEL APPROACH FOR THE IDENTIFICATION AND QUANTITATION OF SPECIFIC MUCLEIC ACID SEQUENCES. IT USES FLUORESCENT, RATHER THAN RADIOACTIVE OR ENZYME-LINKED OLIGODEOXYNUCLEOTIDE PROBES. IT IS A HOMOGENEOUS ASSAY AND DOES NOT REQUIRE ANY SEPARATION STEPS, SUCH AS FILTRATION OR ELECTROPHORESIS. IT IS DESIGNED TO BE ACCURATE, SPECIFIC, SENSITIVE, INEXPENSIVE, RAPID AND EASY TO PERFORM. THESE ATTRIBUTES WOULD ALLOW THIS ASSAY TO BE APPLIED TO THE SCREENING OF BLOOD SAMPLES FOR KNOWN PATHOGENIC VIRUSES. THIS PHASE I STUDY WILL DEMONSTRATE THE FEASIBILITY OF THE DESCRIBED APPROACH USING A SYNTHETIC OLIGODEOXYNUCLEOTIDE TARGET AS A MODEL OF THE VIRAL GENOME.

* information listed above is at the time of submission.

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