Development of a sensor for detecting Paralytic Shellfish Poisoning toxins

Development of a sensor for detecting Paralytic Shellfish Poisoning toxins

Award Information
Agency: Department of Commerce
Branch: National Oceanic and Atmospheric Administration
Contract: WC-133R-17-CN-0077
Agency Tracking Number: 17-1-023
Amount: $119,950.76
Phase: Phase I
Program: SBIR
Awards Year: 2017
Solicitation Year: 2017
Solicitation Topic Code: 8.4.2
Solicitation Number: NOAA-2017-1
Small Business Information
310 Windemere Road, Wilmington, NC, 28405-4028
DUNS: 078782502
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: Unavailable
Principal Investigator
 Sam McCall
 (910) 208-0215
 seatoxresearch@gmail.com
Business Contact
 Sam McCall
Phone: (910) 208-0215
Email: seatoxresearch@gmail.com
Research Institution
N/A
Abstract
Paralytic shellfish poisoning (PSP) due to consumption of contaminated shellfish is an increasing problem is the coastal waters of the United States, particularly in New England and the Pacific Ocean. The symptoms of PSP include vomiting, diarrhea, shortness of breath, confusion, and loss of coordination in both marine animals and humans. In severe cases, PSP toxins can cause respiratory failure and death within hours if care is not provided. PSP is precipitated by neurotoxins produced by marine algae, which accumulate in the flesh and viscera of commercially important shellfish species. Currently, US state agencies monitor for the presence of toxic phytoplankton and when the cell count reaches a set level, shellfish beds are tested for the presence of toxin. However, current methods for detection of PSP toxins have serious drawbacks, including lengthy assay time, cost, and false positive and negative results. The purpose of this project is to develop a fluorescence based receptor binding assay for the detection of PSP neurotoxins. A fluorescent sensor based on a molecule that binds at the PSP toxin receptor site (tetrodotoxin) will allow for low cost rapid assays with high specificity for toxic samples, thus limiting false positive and negative results.

* Information listed above is at the time of submission. *

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