Real-time Assessment of Antimicrobial Concentrations for Personalized Treatment of Infectious Diseases

Award Information
Agency: Department of Defense
Branch: Defense Advanced Research Projects Agency
Contract: D17PC00009
Agency Tracking Number: D162-001-0067
Amount: $149,987.00
Phase: Phase I
Program: SBIR
Solicitation Topic Code: SB162-001
Solicitation Number: 2016.2
Solicitation Year: 2016
Award Year: 2017
Award Start Date (Proposal Award Date): 2016-11-30
Award End Date (Contract End Date): 2017-11-30
Small Business Information
737 Concord Avenue, Cambridge, MA, 02138
DUNS: 557201394
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 Dr. Xinhua Li
 VP Chemistry
 (617) 621-8500
Business Contact
 Kateri Paul
Phone: (617) 621-8500
Research Institution
There is an urgent need to optimize antimicrobial dosing in order to address the prevalence of drug-resistant pathogens and the increase of minimum inhibitory concentrations (MICs) of antimicrobials. Antimicrobials typically have a narrow window of effective concentration or therapeutic indices. If the drug is dosed above this concentration window it becomes toxic. Conversely, if under-dosed, treatment is ineffective and drug resistance can arise. Each patients metabolic profile is unique and thus accurate dosing is difficult to achieve without monitoring. Current monitoring practices rely on laboratory-scale equipment such as high-performance liquid chromatography (HPLC) to quantify drug concentrations in clinical labs and hospitals. We propose to develop a portable device that is capable of performing real-time therapeutic monitoring at the point of care. The device will be similar to commercially available glucose meter containing a disposable testing strip and a small electrochemical detector with data processing functions. Aptamers will be used as recognition elements in the testing strip. A handheld potentiostat will be used for electrochemical analysis. The proposed device will allow clinicians to measure drug concentrations in near real-time, significantly improving treatment outcome and reducing the risk of administering suboptimal doses of antimicrobials.

* Information listed above is at the time of submission. *

Agency Micro-sites

SBA logo
Department of Agriculture logo
Department of Commerce logo
Department of Defense logo
Department of Education logo
Department of Energy logo
Department of Health and Human Services logo
Department of Homeland Security logo
Department of Transportation logo
Environmental Protection Agency logo
National Aeronautics and Space Administration logo
National Science Foundation logo
US Flag An Official Website of the United States Government