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Real-time Assessment of Antimicrobial Concentrations for Personalized Treatment of Infectious Diseases

Award Information
Agency: Department of Defense
Branch: Defense Advanced Research Projects Agency
Contract: D17PC00015
Agency Tracking Number: D162-001-0246
Amount: $150,000.00
Phase: Phase I
Program: SBIR
Solicitation Topic Code: SB162-001
Solicitation Number: 2016.2
Solicitation Year: 2016
Award Year: 2017
Award Start Date (Proposal Award Date): 2016-11-18
Award End Date (Contract End Date): 2017-09-11
Small Business Information
13709 Progress Blvd Box 17
Alachua, FL 32615
United States
DUNS: 192849011
HUBZone Owned: No
Woman Owned: No
Socially and Economically Disadvantaged: No
Principal Investigator
 Steven Benner
 (386) 418-0347
Business Contact
 Linda Jackson
Phone: (386) 418-0347
Research Institution

This project will deliver, in Phase 1, aptamers build from an artificially expanded genetic information system (AEGIS) that bind to at least four of five antimicrobial targets: amphotericin, voriconazole, colistin, gentamicin, and meropenem. These aptamers will be shown in a prototype to bind these targets at relevant concentrations over a relevant dynamic range in 50 L blood samples. In Phase 2, these will be converted into signaling aptamers, which allow visual yes-no readouts to be generated directly from binding. The signal will immediately inform the caregiver whether more antibiotic should be given. This product can be used with a Firebird companion diagnostic that follows treatment progress for target fungal and bacterial pathogens. Most importantly, this project will introduce DARPA to a new disruptive technology, a synthetic biology platform that completes and corrects defects in natural biopolymers, especially DNA and RNA. Developed through DoD basic research investment, these new biopolymers allow diagnostics and therapeutic agents to meet spec unattainable with natural DNA, RNA, and proteins.

* Information listed above is at the time of submission. *

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