Development of Blast-Induced Traumatic Brain Injury Threshold in Rat and Pig and a Scaling Law from Animal to Human

Award Information
Agency: Department of Defense
Branch: Army
Contract: W81XWH-09-C-0068
Agency Tracking Number: O083-H14-3073
Amount: $749,797.00
Phase: Phase II
Program: SBIR
Awards Year: 2010
Solicitation Year: 2008
Solicitation Topic Code: OSD08-H14
Solicitation Number: 2008.3
Small Business Information
Albert I. King
1000 Bretton Lane, Bloomfield Hills, MI, 48304
DUNS: 800027125
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 Clifford Chou
 Technical Leader
 (248) 489-5926
Business Contact
 Albert King
Title: President
Phone: (248) 647-5464
Research Institution
Computational models of rat and pig heads will be developed and validated against pressure data available from previously conducted shock tube experiments by simulating complex blast interaction in a verified and validated shock tube numerical model. Finite Element and Arbitrary Lagrangian-Eulerian techniques will be utilized. Available injury data will be examined in regions of interest generated though model predictions; associated Traumatic Brain Injury mechanism and threshold will be determined for each species. A Design of Computer Experiments will be performed to elucidate a transfer function to link the dissimilar anatomy of small and large animal species for establishing a scaling law. Investigation into the applicability of the proposed transfer function and scaling law from animal to human will be performed using a previously developed human head model. Comparison with real-world blast injury cases and statistical analysis will be used to judge the efficacy of the scaling method to ensure that the results are reasonable in the absence of direct validation data. Results from the human modeling will yield recommendations on the focus of further research and guide future experimental designs to improve the scaling law so that it can be used for developing injury mitigation strategies.

* information listed above is at the time of submission.

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