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Design and Realization of a Dual Function OCM/MPM for Imaging TEMPs

Award Information
Agency: Department of Commerce
Branch: National Institute of Standards and Technology
Contract: SB1341-06-C-0027
Agency Tracking Number: 507-59
Amount: $269,593.00
Phase: Phase II
Program: SBIR
Solicitation Topic Code: N/A
Solicitation Number: N/A
Solicitation Year: N/A
Award Year: 2006
Award Start Date (Proposal Award Date): N/A
Award End Date (Contract End Date): N/A
Small Business Information
60 Hazelwood Dr., Suite 230B, Champaign, IL, 61820
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 Rick Morrison
 () -
Business Contact
 Rick Morrison
Phone: (217) 384-8350
Research Institution
Regenerative medicine is an emerging, interdisciplinary field that will result in new engineered medical products. The introduction of a high-resolution, non-destructive imaging technique that is capable of penetrating deeply into the highly-scattering scaffold medium has the means to accelerate the development and commercial utilization of these novel materials. Multi-photon microscopy (MPM) is based on the detection of the fluorescence emitted by endogenous or exogenous markers. Optical coherence microscopy (OCM) delivers information on the sample's scattering properties. These modalities provide different imaging contrast mechanisms. It is highly desirable to combine both imaging functions into a single instrument. We propose to design and construct a dual function OCM/MPM platform based on expertise developed building a similar system for a biophysics research program at the University of Illinois. COMMERCIAL APPLICATIONS: The unique configuration of the proposed setup, and the opportunity to obtain both anatomical and functional imaging information will make the combined microscope a very useful and attractive imaging tool that could be widely exploited by the scientific community. Particular useful applications can be found in the field of tissue engineering. Other possibilities exist in the field of plant biology to study for example the localization and interaction of different proteins attached to fluorescent proteins in different plants in relation to their development. The combined microscope would also be of potential interest to major microscope vendors that already market two photon microscopes.

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