TARGET VALIDATION METHODS FOR NEMATODE CONTROL AGENTS

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$637,462.00
Award Year:
2002
Program:
SBIR
Phase:
Phase II
Contract:
2R44AI050313-02
Award Id:
60484
Agency Tracking Number:
AI050313
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
DIVERGENCE, INC., 893 N WARSON RD, ST. LOUIS, MO, 63141
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
ANDREW KLOEK
(314) 812-8088
KLOEK@DIVERGENCE.COM
Business Contact:
(314) 812-8091
Research Institute:
n/a
Abstract
Infections by roundworm parasites, called nematodes, result in human mortality and morbidity, especially in subtropical and tropical regions of Africa, Asia, and the Americas. The World Health Organization estimates 2.9 billion people are infected. There are 595 known nematode parasites of vertebrates including hundreds that infect domesticated animals. Widespread use of drugs to control parasites over several decades has led to the evolution of drug-resistant forms of several nematode parasites. The rewards for the development of a new anthelmintic class are substantial. In phase II of our research, we aim to identify -100 genes that are essential to the model nematode Caenorhabditis elegans. We will then clone homologs of these genes from a range of free-living and parasitic nematodes. Using RNAi technology on the free-living nematodes, we will determine which homologs are essential to the nematode lifecycle. Genes that prove essential to all the nematodes tested will be designated as potential nematicide targets. In collaboration with academic laboratories, we will use RNAi to validate target genes in parasitic nematodes. We will test potential inhibitors of the most promising target genes because such compounds could lead to new anti-nematode therapies

* information listed above is at the time of submission.

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