Array microscope image-acquisition system

Award Information
Agency:
Department of Health and Human Services
Amount:
$107,039.00
Program:
SBIR
Contract:
1R43GM069117-01
Solitcitation Year:
N/A
Solicitation Number:
N/A
Branch:
N/A
Award Year:
2003
Phase:
Phase I
Agency Tracking Number:
GM069117
Solicitation Topic Code:
N/A
Small Business Information
DMETRIX, INC.
DMETRIX, INC., 1141 W GRAND RD, STE100, TUCSON, AZ, 85705
Hubzone Owned:
N
Woman Owned:
N
Socially and Economically Disadvantaged:
N
Duns:
N/A
Principal Investigator
 PIXUAN ZHOU
 (520) 722-9510
 JZHOU@DMETRIX.COM
Business Contact
 MICHAEL DESCOUR
Phone: (520) 722-9510
Email: DESCOUR@DMETRIX.COM
Research Institution
N/A
Abstract
DESCRIPTION (provided by applicant): DMetrix is developing an innovative array-microscope slide scanner to generate virtual slides in histopathology. The innovation consists of the use of an array of miniaturized objectives, each measuring approximately 2 mm in diameter and 10 mm in length, slightly staggered in the array, to produce a single, seamless sweep of the microscope slide. The combination of the array microscope optics and the image acquisition system proposed here will allow very rapid scanning, requiring less than 12 seconds for a full microscope slide of 20 mm x 50 mm, at diffraction-limited sampling, The proposed image-acquisition system consists of an optimized, high-speed CMOS image sensor operating at 60 MHz with eight (8) parallel outputs and the accompanying high-speed electronics. The CMOS image sensor is optimized to match the format of the array-microscope optics. The proposed highspeed electronics will be designed to control the image sensor, digitize the image sensor's analog outputs, process the image data in real-time, and compress the image data prior to storage on a host personal computer (PC). The array-microscope virtual-slide scanner will allow digitization of slides at rates 50 times faster than conventional single-optical-axis optical systems. Applications of such a virtual slide scanner are to be found in histopathology, telepathology, pathology education, and pharmaceutical research.

* information listed above is at the time of submission.

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