Diagnostic Microarray Test Based on Comparative Studies of Gene Expression in Humans with Common Inflammatory and Infectious Diseases

Award Information
Agency:
Department of Defense
Branch:
Army
Amount:
$69,136.00
Award Year:
2004
Program:
SBIR
Phase:
Phase I
Contract:
W81XWH-04-C-0039
Agency Tracking Number:
A032-3974
Solicitation Year:
2003
Solicitation Topic Code:
A03-164
Solicitation Number:
2003.2
Small Business Information
DNA SOLUTIONS, INC.
840 Research Parkway, Suite 546, Oklahoma City, OK, 73104
Hubzone Owned:
N
Socially and Economically Disadvantaged:
N
Woman Owned:
N
Duns:
006312594
Principal Investigator
 Tom Kupiec
 President/CEO
 (405) 271-1114
 tkupiec@arlok.com
Business Contact
 Gary Cook
Title: Director of Fianance
Phone: (405) 271-1144
Email: gcook@arlok.com
Research Institution
N/A
Abstract
In order to assure accurate detection of exposure to biological warfare agents or any environmental agents, it is necessary to exclude a variety of common conditions that may confound proper diagnosis. Many groups, including ours , have found that biological warfare agents can stimulate inflammatory systems, the same systems found stimulated in common inflammatory disease such as rheumatoid arthritis, inflammatory bowel disease or ankylosing spondylitis. In order to create an accurate diagnostic tool, it is therefore necessary to define the changes in gene expression that are characteristic of these common inflammatory diseases in clinically accessible tissue (such as peripheral blood) and compare them with the genetic expression level changes characteristic of exposure to biological warfare agents. The database of genes that make this distinction most effectively will be used in the creation of a practical diagnostic test. The addition of the work proposed herein to our existing projects will result in complete expression databases for rheumatoid arthritis, inflammatory bowel disease, hepatitis C and ankylosing spondylitis. This will allow for the creation of a straightforward test reflecting only the gene expression changes indicative of exposure to particular biological warfare agents or existing inflammatory conditions

* information listed above is at the time of submission.

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