SBIR Phase I: Driving Timely Point-of-Care Treatment in Hospitals with a High Precision Bayesian Machine Learning Platform

Award Information
Agency: National Science Foundation
Branch: N/A
Contract: 1746602
Agency Tracking Number: 1746602
Amount: $225,000.00
Phase: Phase I
Program: SBIR
Solicitation Topic Code: SH
Solicitation Number: N/A
Solicitation Year: 2017
Award Year: 2018
Award Start Date (Proposal Award Date): 2018-01-01
Award End Date (Contract End Date): 2018-12-31
Small Business Information
901 N. Market St, Suite 705, Wilmington, DE, 19801
DUNS: 080300426
HUBZone Owned: N
Woman Owned: Y
Socially and Economically Disadvantaged: N
Principal Investigator
 Yanif Ahmad
 (401) 497-2105
Business Contact
 Yanif Ahmad
Phone: (401) 497-2105
Research Institution
The broader impact/commercial potential of this Small Business Innovation Research (SBIR) Phase I project is to provide clinical decision support software that assists inpatient providers in improving care for preventable acute inpatient harms, and thereby reduce mortality and morbidity. This grant develops a cloud-based platform that applies machine learning (ML) algorithms in real-time on data extracted from Electronic Health Records (EHRs) and physiologic monitoring devices attached to a patient. The ML tools employed estimate the degree of reliability for each of the data elements as they are collected and integrates these signals to provide an accurate, individualized risk estimate of patient health over time in order to best guide patient treatment and allocation of hospital resources. Our initial target condition is sepsis, one of the most costly and most deadly diseases in hospitals. This grant develops an end-to-end system to provide risk assessment and implementation of timely treatment. For commercial potential, the underlying core technology can be extended to other clinical scenarios. The proposed project enables scaling of high-precision state-of-the-art Bayesian machine learning techniques that forecast the chance of acute deterioration. This includes tackling the challenges in scaling this machine learning system to function across many care providers, patients, and hospitals. To achieve these goals, this project will develop new methods for running machine learning algorithms in a distributed fashion in cloud computing settings, especially in distinguishing where multiple machines need to coordinate, and arguably more importantly, where they can avoid coordinating in training on data. Further, the project develops software to provide information back to providers so as to enable interventions that can alter patient trajectory. Here the software will encompass how to best use the resulting inferences in guiding care.

* Information listed above is at the time of submission. *

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