Colorimetric Sensors for Chemical and Biological Warfare Agents

Award Information
Agency:
Department of Defense
Branch
Army
Amount:
$99,997.00
Award Year:
2006
Program:
STTR
Phase:
Phase I
Contract:
W9132T-06-C-0037
Award Id:
77875
Agency Tracking Number:
A064-024-0120
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
2001 South First St. Suite 201, Champaign, IL, 61820
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
170941129
Principal Investigator:
Lu Yi
(217) 333-2619
yi-lu@uiuc.edu
Business Contact:
Lu Geng
Senior Scientist
(217) 377-9806
lugengca@gmail.com
Research Institution:
UNIV. OF ILLINOIS AT U-C
Kathy Young
1901 S. First St. , Ste. A
Champaign, IL, 61820
(217) 333-6323
Nonprofit college or university
Abstract
We aim to construct litmus paper-like colorimetric sensors for detection and quantification of chemical and biological agents in water by performing combinatorial selection of DNA aptamers for cyanobacteria toxins such as microcystins and saxitoxins. Aptamers are single stranded DNA that can bind target molecules with high affinity and specificity. Such DNA aptamers are biocompatible, biodegradable, and highly stable even at elevated temperatures and dry conditions, especially when conjugated with nanoparticles. Cyanobacteria toxins are the most encountered toxins in water sources. After obtaining toxin-specific aptamers, DNA-functionalized gold nanoparticles will be used to obtain rapid, autonomous, cost-effective and easily interpretable sensors for soldiers in the field. The sensors will be made into a test strip format that can be easily used by soldiers or other users without a chemistry background. Importantly, the same technology will be applicable to detect a broad range of chemical and biological agents without an extensive support system. In the Phase I research, the feasibility of using the proposed approach will be demonstrated and prototype test kits will be constructed and characterized in Phase II.

* information listed above is at the time of submission.

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