LIPID PHOSPHATASE ASSAYS IN DISEASE AND DRUG DISCOVERY

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$100,000.00
Award Year:
2002
Program:
SBIR
Phase:
Phase I
Contract:
1R43DK062522-01
Award Id:
60896
Agency Tracking Number:
DK062522
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
ECHELON BIOSCIENCES, INC., 420 CHIPETA WAY, STE 180, SALT LAKE CITY, UT, 84108
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
BETH DREES
(801) 588-0455
BDREES@ECHELON-INC.COM
Business Contact:
JOHN WIRTHLIN
(801) 588-0455
JBW@ECHELON-INC.COM
Research Institute:
n/a
Abstract
DESCRIPTION (provided by applicant): Phosphoinositide phosphates (PlPns) are important second messengers in signaling pathways controlling cellular proliferation, survival, morphology, and motility. Disruption of these pathways is common to many disease states, including diabetes, cardiovascular disease, and cancer. Because the activity of lipid second messengers is often determined by their phosphorylation state, the enzymes that act to modify these lipids are central to the correct execution of many signaling events. We propose to develop novel methods for the determination of phosphoinositide phosphatase activity. These assays will be aimed at measuring the activity of the lipid phosphatases PTEN, SHIP1, and SHIP2, which modulate phosphoinositide 3-kinase signaling by conversion of Pl (3,4,5) P3 to Pl (4,5) P2 and Pl(3,4)P2 respectively. These enzymes are important in signaling pathways that regulate insulin sensitivity and allergic and immune response, and which are often altered in carcinogenesis. Because signaling events involving these phsophoinositide phosphatases are often perturbed in disease progression, particularly non-insulin dependent diabetes mellitus (NIDDM) and cancer, these assays should have significant value as research and diagnostic tools as well as drug-screening platforms.

* information listed above is at the time of submission.

Agency Micro-sites


SBA logo

Department of Agriculture logo

Department of Commerce logo

Department of Defense logo

Department of Education logo

Department of Energy logo

Department of Health and Human Services logo

Department of Homeland Security logo

Department of Transportation logo

Enviromental Protection Agency logo

National Aeronautics and Space Administration logo

National Science Foundation logo
US Flag An Official Website of the United States Government