Selective Aortic Arch Perfusion Technologies for Hemorrhage-induced Cardiac Arrest

Selective Aortic Arch Perfusion Technologies for Hemorrhage-induced Cardiac Arrest

Award Information
Agency: Department of Defense
Branch: Defense Health Program
Contract: W81XWH-18-C-0034
Agency Tracking Number: H2-0254
Amount: $999,234.00
Phase: Phase II
Program: SBIR
Awards Year: 2018
Solicitation Year: 2016
Solicitation Topic Code: DHP16-009
Solicitation Number: 2016.1
Small Business Information
5432 W Central Ave Ste B, Toledo, OH, 43615
DUNS: 079906040
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 Gregory L Hays
 (419) 349-5802
 ghays1@haysinc.org
Business Contact
 Julia Hays
Phone: (419) 349-5803
Email: jhays1@haysinc.org
Research Institution
N/A
Abstract
There is increased interest in endovascular hemorrhage control using aortic balloon occlusion to improve outcomes in preventable battlefield death from non-compressible torso hemorrhage (NCTH).Our technology, the SABOT, is the next generation in such catheters, which adds the ability of both selective vascular bed perfusion, bypassing injured beds, and partial perfusion. In phase I the feasibility and proof of concept for bypassing a vascular bed during aortic balloon occlusion was explored.In phase II, the full development of the final prototype will be examined, providing us with selective bypass of multiple vascular beds, and selective, adjustable, partial reperfusion distal to bypassed vascular bed.We will perform a comparison of the SABOT with the REBOA catheter on a swine model using both a renal and liver lacerations to investigate diagnostic and therapeutic uses of the SABOT.Then a comparison of Selective Aortic Arch Perfusion using the SABOT vs the SAAP catheter and ECMO will be performed. Endpoints include: hemodynamic performance, perfusion measures, post occlusion flow and organ failure.

* Information listed above is at the time of submission. *

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