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Rapid SERS-based Detection of Sepsis and TBI Biomarkers

Award Information
Agency: Department of Defense
Branch: Defense Health Program
Contract: W81XWH-18-C-0033
Agency Tracking Number: H17B-004-0072
Amount: $149,999.00
Phase: Phase I
Program: STTR
Solicitation Topic Code: DHA17B-004
Solicitation Number: 2017.0
Timeline
Solicitation Year: 2017
Award Year: 2018
Award Start Date (Proposal Award Date): 2018-02-19
Award End Date (Contract End Date): 2018-09-18
Small Business Information
414 Weill Hall/Cornell University, Ithaca, NY, 14853
DUNS: 078861438
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 Joel Tabb
 (607) 351-2647
 j.tabb@ionicasci.com
Business Contact
 Omar Green
Phone: (626) 676-3076
Email: o.green@ionicasci.com
Research Institution
 City College of New York
 John Lombardi
 160 Convent Avenue
New York, NY, 10031
 (212) 650-6032
 Nonprofit college or university
Abstract
Traumatic brain injury (TBI) often occurs when a sudden trauma or head injury disrupts the function of the brain. Common causes of TBI include damage caused by explosive devices, falls and vehicle or motorcycle accidents. Sepsis is the result of a massive immune response to bacterial infection that gets into the blood. Sepsis often leads to organ failure or injury, and has always been a significant problem on the battlefield; infections ran rampant before the discovery of antibiotics. TBI has been called the signature wound of the wars in Afghanistan and Iraq. The US Department of Defense, calculates over 360,000 soldiers, sailors, airmen, and marines have suffered some form of TBI since the year 2000. Sepsis, while affecting a small proportion of military casualties, has a significant effect in increasing morbidity and mortality. Further, this disease often proceeds rapidly, and manifests itself in unpredictable ways. Ionica Sciences proposes to develop a multiplexed platform that targets biomarkers associated with sepsis and mild to moderate TBI. The Ionica Sciences assay combines target-specific DNA aptamers with Surface Enhanced Raman Scattering (SERS) to rapidly and sensitively detect human biomarker protein tau for TBI and human procalcitonin for sepsis.

* Information listed above is at the time of submission. *

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