Inhibiting Prolyl Hydroxylase to Mimic Natural Acclimatization to High Altitude to Improve Warfighter Performance at High Altitude

Award Information
Agency: Department of Defense
Branch: Special Operations Command
Contract: H9222218P0037
Agency Tracking Number: S17C-001-0021
Amount: $148,496.00
Phase: Phase I
Program: STTR
Solicitation Topic Code: SOCOM17C-001
Solicitation Number: 2017.0
Timeline
Solicitation Year: 2017
Award Year: 2018
Award Start Date (Proposal Award Date): 2018-05-17
Award End Date (Contract End Date): 2018-11-19
Small Business Information
6382 South Geneva Cir, Englewood, CO, 80111
DUNS: 961856973
HUBZone Owned: N
Woman Owned: Y
Socially and Economically Disadvantaged: N
Principal Investigator
 Robert Roach
 (303) 250-8195
 robert.roach@ucdenver.edu
Business Contact
 Barbara Lommen
Phone: (720) 284-7074
Email: bklommen@gmail.com
Research Institution
 University of Colorado AMC
 Pamela Alvarez
 CU Denver Campus Box F-524
12469 E. 17th Place
Aurora, CO, 80045
 (303) 724-1671
 Nonprofit college or university
Abstract
Acclimatization is the long-term adjustment that humans experience when exposed for weeks or months to high altitude. Acclimatization is important in this context because a warfighter who is acclimatized to high altitude is immune to high altitude illness, has superior work capacity, and has cognitive function approaching that found at sea level. In other words, the acclimatized warfighter is optimally equipped for task completion at high altitudes. Currently no drugs are known that will cause a warfighter to become acclimatized. We propose thatpre-treatment with proly hydroxylase inhibitors at low altitude will mimic acclimatization thus creating for warfighters during acute exposure to high altitude immunity to high-altitude illness, along with improved exercise and cognitive performance.

* Information listed above is at the time of submission. *

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