Low-Cost Production of Engineered Proteins in Transgenic Plants

Award Information
Agency: Department of Defense
Branch: Army
Contract: W911NF-06-C-0103
Agency Tracking Number: A064-015-0242
Amount: $99,649.00
Phase: Phase I
Program: STTR
Awards Year: 2006
Solicitation Year: 2006
Solicitation Topic Code: A06-T015
Solicitation Number: N/A
Small Business Information
EDENSPACE SYSTEMS CORPORATION
3810 Concorde Parkway, Dulles, VA, 20151
DUNS: 093504384
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 David Lee
 (703) 961-8700
 lee@edenspace.com
Business Contact
 Bruce Ferguson
Title: President/CEO
Phone: (703) 961-8700
Email: ferguson@edenspace.com
Research Institution
 MICHIGAN STATE UNIV.
 Susan Titus
 301 Administration Building
Lansing, MI, 48824
 (517) 353-9751
 Nonprofit college or university
Abstract
Plants provide an attractive platform for the production of recombinant proteins because they require significantly less capital investment than microbial fermentation systems and can be easily scaled up to produce additional protein. Edenspace proposes to develop a versatile plant expression system with tobacco to produce and purify proteins with therapeutic and industrial purposes. The gene expression cassette to be developed will include a molecular tag to simplify purification of the recombinant protein before being cleaved in order to preserve the biological activity of the protein. To demonstrate this system, Edenspace has created transgenic tobacco with its research partner at Michigan State University, Dr. Mariam Sticklen, expressing the human secretory leukocyte protease inhibitor (SLPI) protein. SLPI is well known for its anti-microbial, wound healing and anti-inflammatory activities, and through this project Edenspace will demonstrate the effectiveness of producing active SLPI in tobacco.

* information listed above is at the time of submission.

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