Low-Cost Production of Engineered Proteins in Transgenic Plants

Award Information
Agency:
Department of Defense
Branch
Army
Amount:
$99,649.00
Award Year:
2006
Program:
STTR
Phase:
Phase I
Contract:
W911NF-06-C-0103
Agency Tracking Number:
A064-015-0242
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
EDENSPACE SYSTEMS CORP.
3810 Concorde Parkway, Dulles, VA, 20151
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
093504384
Principal Investigator:
David Lee
(703) 961-8700
lee@edenspace.com
Business Contact:
Bruce Ferguson
President/CEO
(703) 961-8700
ferguson@edenspace.com
Research Institution:
MICHIGAN STATE UNIV.
Susan Titus
301 Administration Building
Lansing, MI, 48824
(517) 353-9751
Nonprofit college or university
Abstract
Plants provide an attractive platform for the production of recombinant proteins because they require significantly less capital investment than microbial fermentation systems and can be easily scaled up to produce additional protein. Edenspace proposes to develop a versatile plant expression system with tobacco to produce and purify proteins with therapeutic and industrial purposes. The gene expression cassette to be developed will include a molecular tag to simplify purification of the recombinant protein before being cleaved in order to preserve the biological activity of the protein. To demonstrate this system, Edenspace has created transgenic tobacco with its research partner at Michigan State University, Dr. Mariam Sticklen, expressing the human secretory leukocyte protease inhibitor (SLPI) protein. SLPI is well known for its anti-microbial, wound healing and anti-inflammatory activities, and through this project Edenspace will demonstrate the effectiveness of producing active SLPI in tobacco.

* information listed above is at the time of submission.

Agency Micro-sites


SBA logo

Department of Agriculture logo

Department of Commerce logo

Department of Defense logo

Department of Education logo

Department of Energy logo

Department of Health and Human Services logo

Department of Homeland Security logo

Department of Transportation logo

Enviromental Protection Agency logo

National Aeronautics and Space Administration logo

National Science Foundation logo
US Flag An Official Website of the United States Government