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Measuring the Concentration of Host-cell Proteins in Biomanufacturing Using Silicon Nanowire Array Sensors

Award Information
Agency: Department of Commerce
Branch: National Institute of Standards and Technology
Contract: 70NANB18H190
Agency Tracking Number: 076-02-01 (FY18)
Amount: $100,000.00
Phase: Phase I
Program: SBIR
Solicitation Topic Code: N/A
Solicitation Number: 2018-NIST-SBIR-01
Timeline
Solicitation Year: 2018
Award Year: 2018
Award Start Date (Proposal Award Date): 2018-07-30
Award End Date (Contract End Date): 2019-01-31
Small Business Information
173 Bedford Rd., Lincoln, MA, 01773
DUNS: 079689066
HUBZone Owned: Y
Woman Owned: Y
Socially and Economically Disadvantaged: N
Principal Investigator
 Marcie Black
 (954) 471-1357
 marcie@advancedsilicongroup.com
Business Contact
 Marcie Black
Phone: (954) 471-1357
Email: marcie@advancedsilicongroup.com
Research Institution
N/A
Abstract
Our innovation is a low cost, sensitive, quantitative biosensor that can detect many biomarkers on the same chip. Our sensor consists of vertically aligned silicon nanowires. The silicon nanowires’ high surface area to volume ratio makes them sensitive to the environment around them and can thus lead to high sensitivity detection. Each of the nanowires can be functionalized to be sensitive to either specific DNA or proteins. For Phase 1 of this SBIR, we will apply our already demonstrated biosensor to monitoring HCPs in biomanufacturing. In particular, we will functionalize our silicon nanowires to be sensitive to Escherichia coli (E. coli) HCPs. As a first step we will measure a conglomerate of HCPs that are present in potential product, but eventually we will separate the antibodies and measure each protein in a separate sub-sensor.

* Information listed above is at the time of submission. *

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