Rapid Nondestructive Analysis of Opioid Peptide Purity

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$80,248.00
Award Year:
1994
Program:
SBIR
Phase:
Phase I
Contract:
1 R43 DA09216-1,
Agency Tracking Number:
24984
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
Eic Laboratory, Inc.
111 Downey Street, Norwood, MA, 02062
Hubzone Owned:
N
Socially and Economically Disadvantaged:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
Kevin Spencer
(617) 769-9450
Business Contact:
() -
Research Institution:
n/a
Abstract
This project is to develop an analytical instrument and associated protocols for the rapid,nondestructive measurement of molecular and optical purity of the opioid peptides. The instrument willutilize Raman spectroscopy for determination of molecular purity and Raman optical activity (ROA) fordetermination of enantiomeric purity. ROA provides structure-specific optical purity of singlecomponents in the presence of chiral or achiral impurities and is a nondestructive technique. Raman andROA spectroscopy can uniquely determine the purity of the major component as well as uniquely identifyand quantify the impurities that may be present. Phase I objective is to demonstrate the analyticalfeasibility of Raman and ROA spectroscopy for determination of optical and molecular purity of an opioidpeptide. The Phase II objective will be to develop a complete spectral library for all the opioid peptidescurrently stocked by NIDA and to provide NIDA with a prototype ROA instrument.

* information listed above is at the time of submission.

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