ANTIBODY MICROARRAY FOR DETECTION OF TUMOR MARKERS

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: 1R43CA096250-01
Agency Tracking Number: CA096250
Amount: $100,000.00
Phase: Phase I
Program: SBIR
Awards Year: 2002
Solicitation Year: N/A
Solicitation Topic Code: N/A
Solicitation Number: N/A
Small Business Information
EIC LABORATORIES, INC.
EIC LABORATORIES, INC., 111 DOWNEY ST, NORWOOD, MA, 02062
DUNS: N/A
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 MICHAEL WILSON
 (781) 769-9450
 MWILSON@EICLABS.COM
Business Contact
 DAVID RAUH
Phone: (781) 769-9450
Email: DRAUH@EICLABS.COM
Research Institution
N/A
Abstract
DESCRIPTION (provided by applicant): The development of stable antibody microarrays for the simultaneous detection and quantification of multiple tumor markers in blood, urine and tissue is proposed. The arrays will increase the diagnostic value of tumor markers in cancer diagnosis, assessment of treatment, and basic research in molecular profiling, by allowing the simultaneous measurement of multiple groups of markers associated with the same types of cancer. The key innovation is the use of an electrochemically grown matrix (iridium oxide) to immobilize antibodies and maintain their activity, and its application with well-established microelectrode array fabrication methods to produce stable protein microarrays. All the components can be readily miniaturized to circuit board level with very modest power requirements. The design of the arrays is such that they can perform electrochemical simultaneous multianalyte immunoassays (SMAI) from single, small volume samples. In Phase I we will demonstrate the simultaneous detection and quantification of two tumor markers, prostate-specific antigen (PSA) and carcinoembryonic antigen (CEA) using SMAI in order to provide proof-of-concept validation of our antibody microarray system.

* information listed above is at the time of submission.

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