ANTIBODY MICROARRAY FOR DETECTION OF TUMOR MARKERS

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$100,000.00
Award Year:
2002
Program:
SBIR
Phase:
Phase I
Contract:
1R43CA096250-01
Award Id:
59909
Agency Tracking Number:
CA096250
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
EIC LABORATORIES, INC., 111 DOWNEY ST, NORWOOD, MA, 02062
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
MICHAEL WILSON
(781) 769-9450
MWILSON@EICLABS.COM
Business Contact:
DAVID RAUH
(781) 769-9450
DRAUH@EICLABS.COM
Research Institute:
n/a
Abstract
DESCRIPTION (provided by applicant): The development of stable antibody microarrays for the simultaneous detection and quantification of multiple tumor markers in blood, urine and tissue is proposed. The arrays will increase the diagnostic value of tumor markers in cancer diagnosis, assessment of treatment, and basic research in molecular profiling, by allowing the simultaneous measurement of multiple groups of markers associated with the same types of cancer. The key innovation is the use of an electrochemically grown matrix (iridium oxide) to immobilize antibodies and maintain their activity, and its application with well-established microelectrode array fabrication methods to produce stable protein microarrays. All the components can be readily miniaturized to circuit board level with very modest power requirements. The design of the arrays is such that they can perform electrochemical simultaneous multianalyte immunoassays (SMAI) from single, small volume samples. In Phase I we will demonstrate the simultaneous detection and quantification of two tumor markers, prostate-specific antigen (PSA) and carcinoembryonic antigen (CEA) using SMAI in order to provide proof-of-concept validation of our antibody microarray system.

* information listed above is at the time of submission.

Agency Micro-sites


SBA logo

Department of Agriculture logo

Department of Commerce logo

Department of Defense logo

Department of Education logo

Department of Energy logo

Department of Health and Human Services logo

Department of Homeland Security logo

Department of Transportation logo

Enviromental Protection Agency logo

National Aeronautics and Space Administration logo

National Science Foundation logo
US Flag An Official Website of the United States Government