You are here

ANTIBODY MICROARRAY FOR DETECTION OF TUMOR MARKERS

Award Information
Agency: Department of Health and Human Services
Branch: National Institutes of Health
Contract: 1R43CA096250-01
Agency Tracking Number: CA096250
Amount: $100,000.00
Phase: Phase I
Program: SBIR
Solicitation Topic Code: N/A
Solicitation Number: N/A
Timeline
Solicitation Year: N/A
Award Year: 2002
Award Start Date (Proposal Award Date): N/A
Award End Date (Contract End Date): N/A
Small Business Information
EIC LABORATORIES, INC. 111 DOWNEY ST
NORWOOD, MA 02062
United States
DUNS: N/A
HUBZone Owned: No
Woman Owned: No
Socially and Economically Disadvantaged: No
Principal Investigator
 MICHAEL WILSON
 (781) 769-9450
 MWILSON@EICLABS.COM
Business Contact
 DAVID RAUH
Phone: (781) 769-9450
Email: DRAUH@EICLABS.COM
Research Institution
N/A
Abstract

DESCRIPTION (provided by applicant): The development of stable antibody microarrays for the simultaneous detection and quantification of multiple tumor
markers in blood, urine and tissue is proposed. The arrays will increase the
diagnostic value of tumor markers in cancer diagnosis, assessment of treatment,
and basic research in molecular profiling, by allowing the simultaneous
measurement of multiple groups of markers associated with the same types of
cancer. The key innovation is the use of an electrochemically grown matrix
(iridium oxide) to immobilize antibodies and maintain their activity, and its
application with well-established microelectrode array fabrication methods to
produce stable protein microarrays. All the components can be readily
miniaturized to circuit board level with very modest power requirements. The
design of the arrays is such that they can perform electrochemical simultaneous
multianalyte immunoassays (SMAI) from single, small volume samples. In Phase I
we will demonstrate the simultaneous detection and quantification of two tumor
markers, prostate-specific antigen (PSA) and carcinoembryonic antigen (CEA)
using SMAI in order to provide proof-of-concept validation of our antibody
microarray system.

* Information listed above is at the time of submission. *

US Flag An Official Website of the United States Government