You are here

MODEL FOR ELECTRODE TESTING AND REDUCED ANIMAL USE

Award Information
Agency: Department of Health and Human Services
Branch: National Institutes of Health
Contract: 2R44NS039714-02
Agency Tracking Number: NS039714
Amount: $0.00
Phase: Phase I
Program: SBIR
Solicitation Topic Code: N/A
Solicitation Number: N/A
Timeline
Solicitation Year: N/A
Award Year: 2002
Award Start Date (Proposal Award Date): N/A
Award End Date (Contract End Date): N/A
Small Business Information
EIC LABORATORIES, INC. 111 DOWNEY ST
NORWOOD, MA 02062
United States
DUNS: N/A
HUBZone Owned: No
Woman Owned: No
Socially and Economically Disadvantaged: No
Principal Investigator
 STUART COGAN
 (781) 769-9450
 SCOGAN@EICLABS.COM
Business Contact
 R RAUH
Phone: (781) 769-9450
Email: DRAUH@EICLABS.COM
Research Institution
N/A
Abstract

DESCRIPTION (provided by applicant): The development of in vitro models that
provide useful, cost-effective tools for assessing long-term electrochemical
function of chronically implanted electrodes is proposed. The in vitro models
will provide an alternative to animal models for developing experimental
protocols and assessing chronic electrode stability. They will allow long-term
testing of electrochemical function and stability of electrodes under
conditions that reflect the in vivo electrochemical environment without the
expense and variability of conducting such testing in animals. The program
focuses on electrodes for neural recording, functional electrical stimulation
(FES), and chemical sensing in the central nervous system (CNS), although
applications to electrodes in the periphery and to biostability of passive
implants are anticipated. An inanimate model and a living model employing mouse
progenitor cells are proposed. Both models are designed to mimic the
compositional and diffusion environment of the CNS as it affects
electrochemistry at an electrode. The inanimate model was developed in Phase I.
The Phase II program will expand the model to include living cells. The
validity of the inanimate and living models will be evaluated by comparison of
electrode function in the in vitro models with that observed under identical
test protocols in the chronic cat cortex.

* Information listed above is at the time of submission. *

US Flag An Official Website of the United States Government