STAR POLYMER UNIMOLECULAR MICELLES FOR DRUG DELIVERY

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$748,906.00
Award Year:
2003
Program:
SBIR
Phase:
Phase II
Contract:
2R44EB000551-02A2
Agency Tracking Number:
EB000551
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
EIC LABORATORIES, INC.
EIC LABORATORIES, INC., 111 DOWNEY ST, NORWOOD, MA, 02062
Hubzone Owned:
N
Socially and Economically Disadvantaged:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
FEI WANG
(781) 769-9450
FEIWANG@EICLABS.COM
Business Contact:
(781) 769-9450
DRAUH@EICLABS.COM
Research Institution:
n/a
Abstract
DESCRIPTION (provided by applicant): The continued development of a novel drug delivery vehicle for pharmacological treatment of tumors is proposed. The vehicle is a star structured polymer having lipophilic and hydrophilic segments to promote both encapsulation of poorly soluble drugs and solubility of the complex in physiological fluids. In an aqueous environment the star polymer forms a "unimolecular micelle", which shields the encapsulated drug from the outer environment. The stability of the unimolecular structure will minimize early degradation of the encapsulated drug, decrease harmful side effects from premature drug release, and facilitate site-specific drug targeting to selected tissues. Each micelle will have an identical structure and molecular weight that will promote uniform drug loading levels and a predictable, well-controlled drug release rate. The specific aims in the Phase II program are a) to synthesize a range of star polymer structures to develop structure-property relationships, b) to use these structures to develop and optimize the drug encapsulation process for the model anticancer drug etoposide, and, c) by in vitro and in vivo testing at the University of Nebraska Medical Center, determine whether incorporation of anticancer drugs into star polymer micelle enhances therapy of cancer tumors.

* information listed above is at the time of submission.

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