Semiconductor Nanocrystals for Biomedical Imaging

Award Information
Agency:
Department of Health and Human Services
Amount:
$199,889.00
Program:
SBIR
Contract:
1R43AA015644-01
Solitcitation Year:
2005
Solicitation Number:
PHS2005-2
Branch:
N/A
Award Year:
2005
Phase:
Phase I
Agency Tracking Number:
AA015644
Solicitation Topic Code:
N/A
Small Business Information
EIC LABORATORIES, INC.
Eic Laboratories, Inc., 111 Downey St, Norwood, MA, 02062
Hubzone Owned:
N
Woman Owned:
N
Socially and Economically Disadvantaged:
N
Duns:
N/A
Principal Investigator
 FEI WANG
 (781) 769-9450
 feiwang@eiclabs.com
Business Contact
 R RAUH
Phone: (781) 769-9450
Email: DRAUH@EICLABS.COM
Research Institution
N/A
Abstract
The principal objective in Phase I is to demonstrate methodologies for the stabilization and functionalization of luminescent nanoparticles (quantum dots, QDs) to be used in cellular imaging. This will be achieved by encapsulating QDs in two different types of water-soluble polymer delivery vehicles. Both types of polymer will eventually be functionalized with specific targeting ligands in order to facilitate imaging of selected cellular targets. The physicochemical properties that make QDs well suited for such imaging applications include: their quantum yields, small size, narrow emission wavelengths which effect little or no spectral overlap among multiple-size QD tags, their photostability, and their very high absorption efficiencies which obviate the need for high power requirements for excitation. In Phase I, we will synthesize the polymers and use them to encapsulate QDs of defined diameter. Each nanoparticle complex will be characterized in terms of luminescence profile, quantum yield, photostability, and extinction coefficient. These properties will be examined in a variety of environments to determine any pH- or solvent dependent aspects of fluorescence behavior. Both types of encapsulated nanoparticle probes will be used to transfect cultured mammalian cells in order to assess QD luminescence in a physiological milieu.

* information listed above is at the time of submission.

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