Rapid determination of complement activation in the battlefield

Award Information
Agency:
Department of Defense
Branch
Office of the Secretary of Defense
Amount:
$749,981.00
Award Year:
2005
Program:
SBIR
Phase:
Phase II
Contract:
W81XWH-05-C-0072
Award Id:
76509
Agency Tracking Number:
O2-0355
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
111 Downey Street, Norwood, MA, 02062
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
076603836
Principal Investigator:
Michael Wilson
Senior Scientist
(781) 769-9450
mwilson@eiclabs.com
Business Contact:
R. Rauh
President
(781) 769-9450
drauh@eiclabs.com
Research Institution:
n/a
Abstract
The objective of this program is to develop a portable biosensor system to facilitate the rapid evaluation of complement activation in injured personnel. Traumatic blood loss and tissue damage resulting from civilian or battlefield trauma leads to complement activation that, if left untreated, contributes to further tissue damage, shock, respiratory distress syndrome and multiorgan failure. Appropriate inhibition of complement activation is expected to limit tissue damage in such cases. However, since complement is central in the protection against infectious agents, extensive inhibition may lead to overwhelming infection and sepsis. The ability to determine and monitor the extent of complement activation in injured personnel is, therefore, the critical first step for providing appropriate inhibition treatment. In Phase I we successfully demonstrated the feasibility of our sensor technology by measuring two key complement proteins. In Phase II, methods developed in the Phase I will be refined and expanded through optimization of sensor and assay design, expansion of the Phase I sensor to a greater number of assays, and the development of a robust, reliable and portable multianalyte assaying system.

* information listed above is at the time of submission.

Agency Micro-sites


SBA logo

Department of Agriculture logo

Department of Commerce logo

Department of Defense logo

Department of Education logo

Department of Energy logo

Department of Health and Human Services logo

Department of Homeland Security logo

Department of Transportation logo

Enviromental Protection Agency logo

National Aeronautics and Space Administration logo

National Science Foundation logo
US Flag An Official Website of the United States Government