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Rapid determination of complement activation in the battlefield

Award Information
Agency: Department of Defense
Branch: Army
Contract: W81XWH-05-C-0072
Agency Tracking Number: O2-0355
Amount: $749,981.00
Phase: Phase II
Program: SBIR
Solicitation Topic Code: OSD04-H09
Solicitation Number: 2004.3
Solicitation Year: 2004
Award Year: 2005
Award Start Date (Proposal Award Date): 2006-02-02
Award End Date (Contract End Date): 2008-02-02
Small Business Information
111 Downey Street
Norwood, MA 02062
United States
DUNS: 076603836
HUBZone Owned: No
Woman Owned: No
Socially and Economically Disadvantaged: No
Principal Investigator
 Michael Stewart Wilson
 Senior Scientist
 (781) 769-9450
Business Contact
 R. Rauh
Title: President
Phone: (781) 769-9450
Research Institution

The objective of this program is to develop a portable biosensor system to facilitate the rapid evaluation of complement activation in injured personnel. Traumatic blood loss and tissue damage resulting from civilian or battlefield trauma leads to complement activation that, if left untreated, contributes to further tissue damage, shock, respiratory distress syndrome and multiorgan failure. Appropriate inhibition of complement activation is expected to limit tissue damage in such cases. However, since complement is central in the protection against infectious agents, extensive inhibition may lead to overwhelming infection and sepsis. The ability to determine and monitor the extent of complement activation in injured personnel is, therefore, the critical first step for providing appropriate inhibition treatment. In Phase I we successfully demonstrated the feasibility of our sensor technology by measuring two key complement proteins. In Phase II, methods developed in the Phase I will be refined and expanded through optimization of sensor and assay design, expansion of the Phase I sensor to a greater number of assays, and the development of a robust, reliable and portable multianalyte assaying system.

* Information listed above is at the time of submission. *

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